中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (5): 321-323.

• 论著 • 上一篇    下一篇

麻风病患者治愈后肿瘤坏死因子α的研究

高锦程1, 郑碧忠2, 方海林3, 李敏伟3, 虞海燕1   

  1. 1. 浙江医科大学附属邵逸夫医院皮肤科 杭州 310016;
    2. 兰溪市皮肤病防治站;
    3. 浙江医科大学传染病研究所分子免疫室
  • 收稿日期:1996-10-07 修回日期:1997-02-19 出版日期:1997-10-15 发布日期:1997-10-15

Study of Tumor Necrosis Factor α in Cured Leprosy Patients

Gao Jincheng1, Zheng Bizhong2, Fang Hailin3   

  1. Department of Dermatology, First Affiliated Hospital, Zhejiang Medical University, Hangzhou 310016
  • Received:1996-10-07 Revised:1997-02-19 Online:1997-10-15 Published:1997-10-15

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摘要： 为了解麻风病患者治愈后免疫功能状况,研究肿瘤坏死因子α(TNFα)在麻风病免疫反应中的潜在作用和调节异常,进一步探讨麻风病抗感染免疫发病机理,对浙江省兰溪地区各型麻风病治愈者62例(其中BB～LL型和TT～BT型麻风病治愈者各33例和29例)及其直系亲属28例的血清TNFα进行检测,以当地正常人作对照.检测结果各型麻风病治愈者血清TNFα水平均明显低于正常人对照组(P值<0.02～0.01),以瘤型(LL)麻风治愈者降低最显著,而BB～LL与TT～BT麻风病治愈者、麻风病患者直系亲属与正常人对照组之间TNFα均无显著性差异(P值均>0.05).提示麻风病患者治愈多年仍存在TNFα调节紊乱及免疫功能低下,TNFα水平的低下与麻风病患者对麻风杆菌特异性细胞免疫缺陷的发病机理有关.检测麻风治愈者血清TNFα水平与麻风病的分型及预后无关.

关键词: 麻风病, 肿瘤坏死因子α

Abstract: In order to understand the immunofunction in cured patients with leprosy,and study the immunopathogenetic role of TNF-α in leprosy patients and anti infection immuno mechanism of TNF-α in leprosy patients,serum levels of TNF-α of 62 cured leprosy patients and 28 their first generation relatives in Lanxi County,Zhejiang Province were determined,and local normal persons were randomly selected as controls.The results showed that the TNF-α of different types of cured leprosy patients were lower than those of normal controls(P<0.02～0.001).The TNF-α levels of lepromatous leprosy patients were the lowest among all patients.But the TNF-α levels between BB LL patients and TT BT patients,and the TNF-α levels between leprosy patient relatives and normal controls showed no significant difference(P>0.05).The results of this paper suggest that the cured patients still have TNF-α disturbance and decreased immunofunction,and decreased level of TNF-α may relate to the specific immuno deficiency of leprosy patients to M.leprae.It also suggests that the TNF-α level of cured leprosy patients does not correlate with the type and prognosis of leprosy patients.

Key words: Leprosy, Tumor necrosis factor α