中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (5): 318-320.

• 论著 • 上一篇    下一篇

三种香料皮肤刺激和皮肤变态反应及离体皮肤渗透的研究

方丽华, 王侠生   

  1. 上海医科大学皮肤病研究所 200040
  • 收稿日期:1996-10-20 修回日期:1997-07-15 出版日期:1997-10-15 发布日期:1997-10-15
  • 基金资助:
    国家教委博士点基金

The Dermato-toxicology Study of Three Kinds of Perfumes Used in Cosmetics

Fang Lihua, Wang Xiasheng   

  1. Institute of Dermatology, Shanghai Medical University, Shanghai 200040
  • Received:1996-10-20 Revised:1997-07-15 Online:1997-10-15 Published:1997-10-15

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摘要： 为探讨化妆品皮炎的发病机制,对3种香料(异丁香酚、肉桂醛、羟基香茅醛)进行皮肤刺激、皮肤变态反应及离体皮肤渗透的动物实验研究.结果显示:3种香料均是强致敏原,其中肉桂醛还具刺激性.三种香料均能经皮渗透,其中肉桂醛的皮肤渗透性最强;提示化妆品引起的接触性皮炎可能原发刺激与变态反应两种机制同时存在;皮肤渗透性与致敏性有相关关系.

关键词: 刺激, 致敏反应, 离体皮肤渗透, 香料

Abstract: Purpose:To find out the mechanism of cosmetic-related dermatitis.Methods:3 perfumes commonly used in cosmetics were selected (isoeugenol,cinnamic aldehyde and hydroxycitronellal) for laboratory studies of acute skin irritation test (ASIT),multi-irritation skin test (MIST),skin sensitization test (GPMT) and percutaneous penetration in vitro in experimental animals were performed respectively.Results:ASIT showed that none of the three chemicals was irritative.MIST revealed that cinnamic aldehyde was an irritant,and the others were not,the average index of skin irritation was consistent with the severity of histopathologic changes.GPMT showed all of the three chemicals were strong sensitizers.Percutaneous penetration of three kinds of perfumes in vitro showed all of them could be absorbed more or less,and the amount,rate and velocity of penetration of cinnamic aldehyde were the highest among them.Conclusion:The mechanism of cosmetic related dermatitis may be due to primary irritation and/or allergy.The potency of skin sensitization of a chemical is related to its percutaneous penetration.

Key words: Irritation, Sensitization, Percutaneous penetration, Perfume