煤焦沥青烟气诱发小鼠皮肤癌的实验研究

中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (5): 333-334.

煤焦沥青烟气诱发小鼠皮肤癌的实验研究

王瑛¹, 张书岭¹, 王江², 朱钵¹, 赵庆夏²

1. 河南省人民医院皮肤科, 郑州450003;
2. 河南医科大学病理学教研室

收稿日期:1995-11-16 修回日期:1996-02-12 出版日期:1996-10-15 发布日期:1996-10-15

Study on the Induction of Skin Cancer by Coal Tar Pitch Smoke in Mice

Wang Ying¹, Zhang Shuling¹, Wang Jiang²

Department of Dermatology, People's Hospital of Henan Province, Zhengzhou 450003

Received:1995-11-16 Revised:1996-02-12 Online:1996-10-15 Published:1996-10-15

摘要/Abstract

摘要： 为了明确沥青烟气的致皮肤癌作用,我们对沥青烟气进行了动物实验研究。方法:将100只昆明种小鼠随机分为A、B两组。A组小鼠每天在一染毒箱中暴露于煤焦沥青烟气3小时,每周6天,箱内烟气平均浓度为0.17mg/L,4个月后停止,另再观察4个月。B组为空白对照组。结果:8个月中,A组有40只小鼠发生皮肤肿瘤(83.3%),其中32只小鼠有皮肤鳞状细胞癌(66.7%),并有8例发生淋巴结转移。B组无皮肤肿瘤发生。本研究证实:煤焦沥青烟气与液态沥青一样,具有强烈的致皮肤癌作用。

关键词: 沥青, 皮肤癌

Abstract: In this study,100 mice were divided into two groups(group A and B)to study the carcinogenic effect of pitch smoke on skin.Mice in group A were exposed to coal tar pitch smoke(CTPS) 3 hours a day in a box 6 days per week.The average concentration of CTPS in the box was 0.17mg/L. The duration of exposure was 4 months.These mice were followed up for another 4 months.Group B was designed as a control.After eight months,skin neoplasms were found in 40 mice(83.33%)in group A,of which squamous cell carcinomas were found in 32 mice(66.67%).Lymph node metastasis of the carcinoma was found in 8 mice.No skin tumor was found in group B.The result of present study shows that CTPS has strong carcinogenic effect on skin.

Key words: Pitch, Cancer,skin

王瑛, 张书岭, 王江, 朱钵, 赵庆夏. 煤焦沥青烟气诱发小鼠皮肤癌的实验研究[J]. 中华皮肤科杂志, 1996, 29(5): 333-334.

Wang Ying, Zhang Shuling, Wang Jiang. Study on the Induction of Skin Cancer by Coal Tar Pitch Smoke in Mice[J]. Chinese Journal of Dermatology, 1996, 29(5): 333-334.