中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (4): 243-245.

• 论著 • 上一篇    下一篇

药疹患者血液粘弹特性变化的研究

熊霞1, 周光平2, 陈槐卿3   

  1. 1. 四川省泸州医学院附属医院皮肤科 646000;
    2. 华西医科大学附属第一医院皮肤科;
    3. 生物医学工程研究室
  • 收稿日期:1995-08-31 修回日期:1995-10-24 出版日期:1996-08-15 发布日期:1996-08-15

The Changes of Viscoelastic Properties of Whole Blood in Patient with Drug Eruption

Xiong Xia1, Zhou Guangpin2, Chen Huaiqing3   

  1. Department of Dermatology, the Afiliated Hospital, Luzhou Medical Colege, Luzhou, Sichuan 646000
  • Received:1995-08-31 Revised:1995-10-24 Online:1996-08-15 Published:1996-08-15

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摘要： 为了进一步探讨药疹的发病机理及为其提供新的治疗途径,采用Low Shear-30流变仪、微量红细胞压积仪,测定72例病情程度不同的药疹患者血液粘弹特性、血粘度参数,按年龄和性别分别与相应对照组比较,且将30例中度严重型(中型)患者随机分为二组,分别用丹参及钙剂治疗.结果显示:各型患者红细胞压积(HCT)无显着性差异(P>0.05);轻型组仅血浆粘度(ηp)较对照组增高(P<0.01),余参数无明显变化;中、重型患者除ηp、HCT外,高低切变率下全血表观粘度(η51.2、η0.512)、红细胞聚集指数(AI)、粘性分量(η')、弹性分量(η")、储存模量(G')均较正常明显增高(P<0.05～0.001),且上述各参数重型较中型、中型较轻型增高显着(P<0.05～0.001);中型患者经丹参治疗后各参数较疗前明显降低(P<0.05),而钙剂组治疗前后各参数值无明显变化(P>0.05).上述结果提示药疹患者血粘度的变化为HCT以外的其他因素所致;随着病情加重,红细胞变形性降低和红细胞聚集性增强越明显,为病情判断提供了参考指标.药疹患者血液粘弹特性的异常可能影响药疹的发病及病理过程;对药疹患者可给予丹参、己酮可可碱等药物治疗.

关键词: 药物性皮炎, 血粘弹特性, 丹参

Abstract: In order to study the mechanism of drug eruption and toprovide a new approach for treatment, we measured the viscoelastic parameters of the whole blood in 72 cases of drug eruption with diferent degrees of severity using Low Shear-30 rheometer and microhematocritor, and 30 patients with moderate severity were randomly divided into two groups,and were treated with Salvia miltiorrhiza and calcium gluconate respectively.The results showed:The hematocrit (HCT) levels showed no significant diference in diferent groups (P>0.05).Plasm aviscosity(ηp)increased in the mild group(P<0.01).ηp,η0.512,η51.2,aggregation index of RBC(AI),η',η" and G' were elevated in the moderate group (P<0.05～0.01).Except ηp and HCT,all parameters in severe group were more markedly increased than those in the moderate group.It was clear that the change of blood viscosity was not caused by HCT.The more severe was the patient,the more in creased was the aggregation of RBC,but the less was the deformability of RBC.These parameters provided an objective criterion for judging the severity of drugeruption.It is the author's opinion that the hemorheological abnormalities may be one of the important factors in the development of drug eruption,and Salvia miltiorhiza may have good the rapeutic efect for drug eruption.

Key words: Dermatitis medicamentosa, Viscoelasticity of blood, Salvia miltiorrhiza