中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (3): 181-182.

• 论著 • 上一篇    下一篇

双黄连体外抗解脲支原体试验及临床疗效观察

表贞淑, 岳丽爽, 马燕燕, 白义杰, 付玉坤   

  1. 辽宁省人民医院皮肤科
  • 收稿日期:1995-05-15 修回日期:1995-10-14 出版日期:1996-06-15 发布日期:1996-06-15

Study on Anti-Ureaplasma Urealyticum Action in Vitro and Therapeutic Efect of Shuanghuanglian to Non-gonococcal Urethritis

Biao Zhenshu, Yue Lishuang, Ma Yanyan   

  1. Department of Dermatology, The People's Hospital of Liaoning Province, Shenyang 110015
  • Received:1995-05-15 Revised:1995-10-14 Online:1996-06-15 Published:1996-06-15

摘要: 为了探索非淋菌性尿道炎(NGU)更有效的疗法,对中药提取物双黄连进行了体外抗解脲支原体(UU)试验研究及临床治疗观察.体外试验采用药基法,即以UU液体培养基,将双黄连倍比稀释后进行培养观察.共观察临床分离的50个菌株.临床上采用双黄连静脉滴注治疗62例UU感染的NGU患者,60mg·kg·次,每日1次,10次为一个疗程.结果:双黄连对UU的MIC0.05~0.4mg/ml,MIC50≤0.2mg/ml,MIC90≤0.4mg/ml.临床上一个疗程治愈率78.0%,有效率88.1%,病原学治愈率78.0%.合并沙眼衣原体(CT)感染的7例中有4例治愈.副作用:有3例发生荨麻疹,除此未见其他副作用.双黄连体外试验对UU有显著抗菌活性,临床应用获得较佳疗效,副作用轻微.本品不但对UU感染有效,对CT感染亦有一定效果,值得临床上进一步研究.

关键词: 非淋菌性尿道炎, 解脲支原体, 双黄连

Abstract: In order to find out an efective drug to treat nongonococal urethritis(NGU),we studied anti-Ureaplasma urealy ticum(UU) action in vitro and therapeutic efects of Shuanghuanglian injection,an extract of Chinese herb.50 strains of UU were cultured in a liquid medium in which Shuanghuanglian was added in doubling dilutions.Clinicaly,Shuanghuanglian injection was used to treat 62 patients with NGU caused by UU,60mg/kg/day,for ten days.

Key words: Nongonococal urethritis, Ureaplasma urealyticum, Shuanghuanglian