中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (1): 5-8.

• 论著 •    下一篇

家族过敏史在遗传过敏性皮炎患者中的意义

田润梅, 康克非   

  1. 上海医科大学附属华山医院皮肤科, 200040
  • 收稿日期:1995-02-27 修回日期:1995-08-15 出版日期:1996-02-15 发布日期:1996-02-15

Significance of the Family Atopic History in Patient with Atopic Dermatitis

Tian Runmei, Kang Kefei   

  1. Department of Dermatology, Hua Shan Hospital, Shanghai Medical University, Shanghai 200040
  • Received:1995-02-27 Revised:1995-08-15 Online:1996-02-15 Published:1996-02-15

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摘要： 为了解家族过敏史在遗传性过敏性皮炎(AD)患者临床及实验室方面所起的作用,我们将确诊为AD的年龄>2岁的158例患者按有无家族过敏史分成二组(89和69例),分别观察个人及家族过敏史、皮损形态和范围、五项伴发症状及某些实验室指标。结果显示有或无家族过敏史的患者发病年龄<2岁者分别占92.1%和84.1%,连续发病55.1%和43.5%,间断时间平均5.7年和9.6年,呼吸道过敏的平均发生年龄分别为哮喘4.1岁和6.2岁,过敏性鼻炎8.8岁和11.1岁。皮损范围和形态、五项伴发症状差异不大,个人及家族中以哮喘患病率高.并以Ⅰ、Ⅱ级亲属较高。个人及家族有呼吸道过敏史者其血清总IgE高于无过敏史者(P<0.01)。其他各项指标P>0.05。结论:有家族过敏史的AD患者比无家族过敏史者发病年龄较早.连续发病较多,间断时间较短,呼吸道过敏的平均发生年龄较早,个人及家族中以哮喘患病率高,近亲的过敏史比远亲更有价值,个人及家族有呼吸道过敏对患者总IgE有重要影响,并且总IgE升高与皮损严重度一致。

关键词: 皮炎,特应性, 家族, 过敏

Abstract: To evaluate the relationship between the family atopic history(FAH) and clinical,laboratory parameters and diagnosis in patients with atopic dermatitis(AD).One hundred and fifty-eight AD patients were included in this study and the patients were divided into two groups,89 eases (56.3%) with FAH and 69 cases(43.7%) without FAH.The personal and family atopie history,the distribution and morphology of the lesions,five associated clinical manifestations and laboratory tests were performed in 158 cases with AD.In comparison of the patients with FAH with the cases without FAH,the age of onset in AD patients under two years was 92.1% and 84.1%,respectively;persistent course, 55.1% and 43.5%;the average time of intermittent course,5.7 years and 9.6 years;the age of onset of respiratory tract allergy(AR),4.1 years and 6.2 years in cases with asthma,8.8 years and 11.1 years in allergic rhinitis (R).The morbidity of asthma in patients with personal and family atopic history was higher and it was higher in Ⅰ and Ⅱ generation also.The levels of serum IgE in AD patients with personal and family history of AR were higher than those in without AR history(P<0.01).In AD patients with FAH,the age of onset was younger,persistent course was longer,intermittent course was shorter. The morbidity of asthma was higher in the patients with personal and family atopic history and the atopic history of close generation was more important than those of distant generation.In AD patients with personal and family history of AR,the levels of serum IgE were significantly higher and elevated levels of serum IgE correlated with the severity of dermatitis.

Key words: Dermatitis,atopic, Family, Hypersensitivity