麻风病患者经国产氟嗪酸治疗前后麻风菌活力的测定

中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (6): 384-386.

麻风病患者经国产氟嗪酸治疗前后麻风菌活力的测定

沈建平¹, 李文忠¹, 王荷英¹, 叶干运¹, 吴铁强¹, 周武庆¹, 王洪春¹, 魏万惠¹, 黄文标², 刘风梧², 张世保², 何兰奉²

1. 中国医学科学院, 中国协和医科大学皮肤病研究所, 南京, 210042;
2. 云南省皮肤病防治研究所

收稿日期:1995-01-26 修回日期:1995-04-12 出版日期:1995-12-15 发布日期:1995-12-15

Viability of M. leprae in Lepromatous Leprosy Patients During A Short-term Clinical Trial of Home-made Ofloxacin

Shen Jianping¹, Li Wenzhong¹, Wang Heying¹

Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042

Received:1995-01-26 Revised:1995-04-12 Online:1995-12-15 Published:1995-12-15

摘要/Abstract

摘要： 为研究国产氟嗪酸对多菌型麻风患者的疗效,11例新发未治界线类偏瘤型(BL)/瘤型麻风(LL)和2例氨苯砜单疗复发BL/LL患者以国产氟嗪酸400mg/d治疗12周,有8例患者在疗前、疗后6、9和12周时分别取活检作鼠足垫接种以测定药物对麻风菌活力的影响.其中5例标本接种裸鼠,3例标本接种CFW小鼠.鼠足垫试验结果显示,几乎所有疗前标本接种的裸鼠和大部分小鼠见有麻风苗繁殖,治疗6周或6周以上标本接种的裸鼠或小鼠均未见麻风菌繁殖.结果示国产氟嗪酸是一种较强的杀麻风菌药物,其疗效与国外文献报告相似.研究结果也为该药组成新的治疗方案提供了科学依据.

关键词: 氟嗪酸, 麻风, 分支杆菌

Abstract: In order to study the effects of home-made ofloxacin on lepromatous leprosy patients, the viability of M.leprae in the patients during a short-term clinical trial with home-made ofloxacin was detected.Eleven untreated BL/LL leprosy patients and 2 relapsed BL/LL leprosy patients after dapsone monotherapy were treated with home-made ofloxacin 400mg daily for 12 weeks.In & of these patients skin biopsies taken from the lesions were inoculated into the mouse foot pad at 0, 6,9 and 12 weeks of the treatment for detecting the viability of M.leprae.Out of the & biopsies, 5 were inoculated into the nude mice, 3 into CFW normal mice.The results of the mouse foot pad experiment showed that nearly all nude mice and the majority of the normal mice inoculated with biopsies taken before treatment had multiplication of M.leprae in their foot pads, but no growth of M.leprae was found in all nude mice and normal mice inoculated with biopsies taken at the end of 6 weeks and thereafter.The results of the study demonstrate that the home-made ofloxacin is a strong bactericidal drug against M.leprae.The results also provide a scientific basis for including this drug in the multi-drug therapy regimen of leprosy.

Key words: Ofloxacin, Leprosy, Mycobacterium leprae

沈建平, 李文忠, 王荷英, 叶干运, 吴铁强, 周武庆, 王洪春, 魏万惠, 黄文标, 刘风梧, 张世保, 何兰奉. 麻风病患者经国产氟嗪酸治疗前后麻风菌活力的测定[J]. 中华皮肤科杂志, 1995, 28(6): 384-386.

Shen Jianping, Li Wenzhong, Wang Heying. Viability of M. leprae in Lepromatous Leprosy Patients During A Short-term Clinical Trial of Home-made Ofloxacin[J]. Chinese Journal of Dermatology, 1995, 28(6): 384-386.

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