中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (4): 219-221.

• 论著 • 上一篇    下一篇

皮肤恶性淋巴瘤核形态测量和增殖率研究

邱丙森1, 高歌2   

  1. 1. 上海医科大学皮肤病学研究所 200040;
    2. 上海医科大学卫生统计教研室
  • 收稿日期:1994-09-29 修回日期:1994-12-19 出版日期:1995-08-15 发布日期:1995-08-15
  • 基金资助:
    国家自然科学基金

Study on Karyomorphometry and Proliferating Rate of Cutaneous Malignant Lymphomas

Qiu Bingsen1, Gao Ge2   

  1. Institute of Dermatology, Shanghai Medical University, Shanghai 200040
  • Received:1994-09-29 Revised:1994-12-19 Online:1995-08-15 Published:1995-08-15

PDF (PC)

350

赞

摘要： 对29例皮肤恶性淋巴瘤(CML)和7例皮肤淋巴样细胞浸润性疾病(CLI)中各例同一皮肤活检石蜡包埋标本同时回顾性检测核形态和增殖率,结果示统计学上CML的核体积(NVs)、银染核仁组成区蛋白计数(AgNORs)和增殖细胞核抗原(PCNA-PC10)指数(PC10Is)与CLI的差异有权显著意义。NVs和PC10Is与患者死亡相关。NVs与AgNORs也相关。

关键词: 淋巴瘤, 核形态测量, 细胞增殖率

Abstract: The same paraffin-embedded specimen of skin biopsy from each of 29 patients with cutaneous malignant lymphomas (CML) and 7 patients with cutaneous lymphoid infiltrates (CLI) was estimated simultaneously and retrospectively by karyomorphometry and proliferating rate assay. The results showed that the differences in nuclear volumes (NVs), count of argyrophilic nucleolar organizer regions(AgNORs) and proliferating cell nuclear antigen (PCNA-PC10) indices (PC10Is) between CML and CLI were statistically very significant. The NVs and PC10Is were correlated to the death rate of patients. NVs were also correlated to AgNORs.

Key words: Lymphoma, Karyomorphometry, Cell proliferating rate