中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (1): 3-4.

• 论著 •    下一篇

斑秃家族患病调查及其研讨

曾昭明, 郑际华, 曾敬思   

  1. 同济医科大学附属协和医院皮肤性病学教研室 武汉 430022
  • 收稿日期:1994-01-11 修回日期:1994-07-27 出版日期:1995-02-15 发布日期:1995-02-15

Genealogical Investigation on Patients with Alopecia Areata

Zeng Zhaoming, Zheng Jihua, Zeng Jingsi   

  1. Department of Dermatology, Union Hospital of Tongji Medical University, Wuhan 430022
  • Received:1994-01-11 Revised:1994-07-27 Online:1995-02-15 Published:1995-02-15

PDF (PC)

317

赞

摘要： 报道原发性斑秃1210例,发现有家族史者75例(6.2%),其家族中共有患者163例,患病率为14.91%.家族患者之间亲缘关系分属于:Ⅰ级亲属142例(87.12%),Ⅱ级17例,Ⅲ级4例,患者发病在同一个世代者33户,70例;发于两世代40户,87例;三世代2户,6例.有4例单合子双胎,今尚未见其孪生者同发斑秃.对遗传因素与斑秃发病之关系进行了分析研讨.

关键词: 斑秃, 遗传, 患病率

Abstract: In the genealogical investigation into 1210 patients with alopecia areata(AA),we found 75 cases with a positive family history of AA,the familial incidence was 6.2%.The incidence of AA in the 75 families (1093 cases) was 14.91% (163 cases).In these families,there were 142 patients in first-grade relatives of the family members,17 in second-grade,and 4 in third-grade.We observed 70 cases in 33 families within one generation,87 cases in 40 families within two succesive generations,and 6 cases in 2 families within three successive generations,four pairs of monozygotic twins appeared in this investigation,but just one of each pair was affected.The relationship between pathogenesis of AA and genetic factor has been discussed.

Key words: Alopecia areata, Familial Incidence