中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (5): 291-293,330.

• 论著 • 上一篇    下一篇

紫外线辐射的尿刊酸对小鼠迟发型超敏反应抑制的研究

毕志刚1, 徐赞2, 王韬2   

  1. 1. 南京医科大学第一附属医院皮肤科, 210029;
    2. 江苏省人民医院临床实验研究室
  • 收稿日期:1993-10-25 修回日期:1994-01-26 出版日期:1994-10-15 发布日期:1994-10-15
  • 基金资助:
    国家自然科学基金

Suppression of Delayed Type Hypersensitivity Response to DNP6OVA in Mouse by UV-Irradiated Urocanic Acid

BI Zhi-Gang1, XU Zan2   

  1. WANG Tao Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029
  • Received:1993-10-25 Revised:1994-01-26 Online:1994-10-15 Published:1994-10-15

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摘要： 建立了以小鼠耳厚的增加反映对DNP6-OVA抗原的迟发型超敏反应(DTH)的动物模型,以观察经紫外线辐射的顺式尿刊酸(cis-UCA)对小鼠DTH的抑制程度。结果注射cis-UCA的小鼠耳厚增加与对照组有显着性差异(P<0.01),而注射反式尿刊酸(trans-UCA)的小鼠耳厚增加与对照无显着性差异(P>0.05).表明在对DNP6-OVA的免疫应答中,cis-UCA能够抑制细胞免疫反应。

关键词: 尿刊酸, 紫外线, 超敏感性,迟发型

Abstract: In order to investigate the effects of cis-UCA on cell-mediated immunity, we established a murine model of DTH response to DNP6OVA which is indicated by the increasing in the ear thickness of the mouse after resensitization, compared with those of the mouse injected with 200 g cis-UCA and trans-UCA intraperitoneally (i.p.). The average of the increasing in ear thickness of each group was 9.1±1.13×10-2 mm (n=8, the number of ears) for the group administrated with cis-UCA; 17.45±0.88×10-2 mm (n=8) for the group administrated with trans-UCA; 16.43+1.83×10-2 mm(n=7) for control group. It is suggested that there are immunosuppression of DTH response to DNP6OVA in mouse administrated with ets-UCA and no effecs of trans-UCA on this response.

Key words: Urecanic acid Ultraviolet rays Hypersensitivity, delayed type