中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (3): 144-145,189.

• 论著 • 上一篇    下一篇

玫瑰糠疹与柯萨奇B组病毒感染关系的研究

宋馥香1, 许丽艳2, 段正芳1, 巫毅1, 张鸿源2   

  1. 1. 白求恩医科大学第二临床医学院皮肤科 130041;
    2. 白求恩医科大学应用基础医学研究所
  • 收稿日期:1993-07-06 修回日期:1993-11-12 出版日期:1994-06-15 发布日期:1994-06-15
  • 基金资助:
    吉林省卫生厅资助课题

Study on the Relationship between Pityriasis Rosea and Coxsackie B Virus infection

SONG Fu-Xing1, XU Li-Yan2, DUAN Zheng-Fang1   

  1. Norman Bethune Medical University, Changchun 130041
  • Received:1993-07-06 Revised:1993-11-12 Online:1994-06-15 Published:1994-06-15

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摘要： 用病毒学及免疫学方法研究了玫瑰糠疹与柯萨奇B组病毒感染的关系.结果表明,急性期患者血清抗柯萨奇B组病毒特异性IgM的阳性率明显高于健康对照组,血清循环免疫复合物的含量急性期明显高于恢复期,中和试验和病毒分离都证明患者体内有柯萨奇B组病毒感染.这些结果提示,玫瑰糠疹的发病与柯萨奇B组病毒感染有直接关系,而造成免疫病理损伤的原因是柯萨奇B组病毒与其相应抗体形成的循环免疫复合物.

关键词: 玫瑰糠疹, 柯萨奇病毒B

Abstract: Relationship between pityriasis rosea and Coxsackie B virus (CBV) infection was studied by virologic and immunologic methods.The results indicated that the positive rate of serum anti-CBV(B group)IgM antibody of the patients in acute stage was significantly higher than that of heahhy control.The level of serum circulating immune complex in acute stage was significantly higher than that in convalescent stage.Neutralization tests and virus isolation also proved that the patients was infected by CBV.These results suggest that the pathogenesis of pityriasis rosea may be related to CBV in fection,and CIC,which was composed of CBV and its antibody,led to the immunopathological damage of the patients.

Key words: Pityriasis rosea, Coxsackie B viruses