中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (6): 343-345.

• 论著 • 上一篇    下一篇

SLE患者可溶性白介素2受体水平改变及其意义

郑敬1, 孙国均1, 劳力民1, 蔡绥勃1, 杨骅2, 张行2   

  1. 1. 浙江医科大学附属第二医院皮肤科, 杭州 310009;
    2. 浙江医科大学肿瘤研究所
  • 收稿日期:1992-09-14 修回日期:1992-12-28 出版日期:1993-12-15 发布日期:1993-12-15

Levels of Soluble Interleukin-2 Receptor and Clinical Significance in Patients with Systemic Lupus Erythematosus

ZHENG Min1, SUN Guo-Jun1   

  1. The second Affiliated Hospital Zhejiang Medical University, Hangzhou 310009
  • Received:1992-09-14 Revised:1992-12-28 Online:1993-12-15 Published:1993-12-15

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摘要： ELISA双抗体夹心法测定34例SLE患者血清可溶性白介素2受体(sIL-2R)水平分析疾病活动性与sIL-2R水平以及与其他临床和实验室指标的关系.结果如下:①SLL患者的sIL-2R水平明显异常增高.②SLE患者sIL-2R水平与疾病活动性呈显著正相关,而与外周血淋巴细胞计数,免疫球蛋白水平以及坑dsDNA抗体水平均无平行关系.③SLE患者sIL-2R水平超过400 U/ml上时可能提示脏器损害及浆膜炎的存在.分析表明,在同一病例作连续sIL-2R水平测定有助于了解SLE患者疾病活动和治疗效果.

关键词: 红斑狼疮,系统性, 受体,白介素

Abstract: The levels of soluble IL-2R were measured by a ELISA sandwich assay in 34 patients with systemic lupus erythcmatosus and 30 normal controls.The relationship between the levels of sIL-2R and disease activity,other clinical and laboratory parameters were evaluated.The results were as follows:①The levels of sIL-2R were significantly elevated in SLE patients compared with controls(P<0.0001).②Elevated levels of soluble IL-2R correlated positively with the disease activity index(P<0.001),but did not correlated with peripheral blood lymphocyte count,immunoglobulin level and positivity of anti-dsDNA antibodies.③levels of sIL-2R over 400 U/ml appeared to indicate the existence of visceral involvement and/or serositis,pneumonitis,carditis etc.in SLE patients.The results showed that serial measurements of sTL-2R level may contribute to understanding disease activity and therapeutic evaluation.

Key words: Lupus, erythematosus,systemic, Reccpotor,interleukin-2