中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (4): 207-209.

• 论著 • 上一篇    下一篇

SLE病人雷诺现象与抗RNP抗体的关系

李明, 施守义   

  1. 上海医科大学华山医院皮肤科, 200040
  • 收稿日期:1992-06-10 修回日期:1993-01-02 出版日期:1993-08-15 发布日期:1993-08-15

Study of the relationship between Raynaud’s phenomenon and anti-RNP antibodies in patients with SLE

LI Ming, SHI Shou-Yi   

  1. Department of Dermatology, Hua Shan Hospital, Shanghai Medical Uniaersity, Shanghai 200040
  • Received:1992-06-10 Revised:1993-01-02 Online:1993-08-15 Published:1993-08-15

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摘要： 以兔胸腺可提取核抗原(ENA)为抗原,采用免疫印迹技术(IBT)等方法,对61例SLE病人血清ENA多肚杭体谱进行了检测.30例具有雷诺现象(RP)的病人,抗RNP多肤抗体谱中抗73000、抗A(32000),抗B'(G29000)和抗C(17500)多肤抗体的阳性率显著高于31例无RP的病人.对本组RP病人和杭RNP抗体阳性病人的临床特征进行了比较,提示坑RNP抗体可能不是引起SLE病人 RP发生的唯一因素,而且该抗体可能与RP病人肾损害的发生率低无关.

关键词: 雷诺病, 红斑狼疮,全身性, 抗体特异性

Abstract: The serum antibodies to extractable nuclear antigen (ENA) polypeptides in 61 SLE patients with and without Raynaud's phenomenon (RP).detected by immunoblotting technique (IBT), etc. The results showed that the positive rates of anti-RNP antibxlies to 730Q0, A (32000), B'(29000) arttl C (17500) polypeptides were significatrtly higher in 30 patients with RP than those in 31 patients without RP. By comparing the clinical features of the RP patients and the patients with anti-RNP antibodies, it was indicated that the anti-RNP antibodies might not be the only pathogenic factor causing the RP in patients with SLE, and the antibodies might not be related to a lower renal disorder prevalence in SLE patients with RP.

Key words: Raynaud’s disease, Lupus erythematosus, systemic, Antibody specibcity