中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (2): 90-92.

• 论著 • 上一篇    下一篇

神经性皮炎和结节性痒疹皮损组织的免疫表现型

陆东庆1, 陈洪铎2, 王雅坤1   

  1. 1. 中国医科大学附属第一医院皮肤科, 沈阳, 110001;
    2. 导师
  • 收稿日期:1992-01-24 修回日期:1992-07-09 出版日期:1993-04-15 发布日期:1993-04-15

Immunoohenotyping of the skin lesions in neuroderanatitis and prurigo nodularis

LU Dong-Qing1, CHEN Hong-Duo2, WANG Ya-Kun1   

  1. Department of Dermatology, No.1 Hospital, China Medical University, Shenyang 110001
  • Received:1992-01-24 Revised:1992-07-09 Online:1993-04-15 Published:1993-04-15

PDF (PC)

228

赞

摘要： 用一系列单克隆抗体及ABC免疫酶标技术,对17例神经性皮炎和5例结节性痒疹的皮肤组织进行观察.结果表明:①真皮内的浸润细胞主要为T淋巴细胞,未见B淋巴细胞.②泛发性神经性皮炎和结节性痒疹皮损表皮内郎格罕细胞密度增加.③多数病损的表皮角阮细胞表达HLA-DR抗原.④所有病损表皮上部的角阮细胞均表达CD36(OKM5)抗原.我们推侧:细胞免疫可能参与神经性皮炎和结节性痒疹的病理过程.

关键词: 神经性皮炎, 痒疹, 免疫表现型

Abstract: We used an avidin-biotin-complex immun-operoxidase technique with various monoclonal antibodies to investigate the skin lesions from 17 cases of neurodermatitis and 5 cases of prurigo nodularis. Our results showed that:(1)The drrmal infiltrates were composed predominantly of T lymphocytes, while no B lymphocyte vvas observed. (2) Increased epidermal Langerhans cells deaaities were found in genetaliztd neurodermatitis and prurigo noslularis. (3) Expression of HLA-DR antigen on keratinocytes was found in most of the cases. (4) Expression of CD 36 (OKMS) antigen on keratino-cytes was found in the upper epidermis in all cases.We suggest that cell-mediated immunity may be involved in the pathological process in neurodermatitis and prurigo nodularis.

Key words: Neurodermatitis, Prurigo, Immunophenotyping