SLE的水疱发疹及其与抗基底膜抗体的关系

中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (2): 73-76.

SLE的水疱发疹及其与抗基底膜抗体的关系

林麟, 靳培英, 是元甫, 桑红桂, 徐文严

中国医学科学院皮肤病研究所, 南京, 210042

收稿日期:1992-03-25 修回日期:1992-11-10 出版日期:1993-04-15 发布日期:1993-04-15

SLE with Vesicdobnllons Erupdons and the Relationship of Anti-BMZ Antibodics to Blistering

LIN Lin, JIN Pei-Ying

Institute of Dermatodagy, Chinese Academy of Medical Sciences, Nanjing 210042

Received:1992-03-25 Revised:1992-11-10 Online:1993-04-15 Published:1993-04-15

摘要/Abstract

摘要： 报告3例有水疱表现的SLE.在临床、组织病理、免疫病理、免疫电镜方面进行了观察.通过NaCl分离皮肤为底物,用IIF进一步检测了无水疱病史的SLE77例,SOLE 3例.有58例SLE,2例SCLE和大疱性红斑狼疮(BSLE)一样,血清中存在着抗BMZ抗体.我们认为5LE的抗BMZ抗体和水疱发生并无必然的关系,不能以此杭体的存在为根据,来判断HSLE是SLE并发其它水疱性皮肤病.

关键词: 红斑狼疮,全身性, 抗基底膜杭体

Abstract: The clinical, histological, immunopathological features of three bullous SLE (BSLE) patients were described. Direct IEM was performed in one case. With IIF using 1.0 M NaCl-splitted human skin as substrate, the anti-BMZ antibodies in the sera of 77 cases of SLE and 3 cases of SOLE were screened. The results demonstrated that there were a low titre of anti-BMZ antibodies in 58 saes of SLE, 2 cases of SOLE, as well as 3 cases of BSLE. The authors consider that anti-SMZ antibodies are not always associated with blistering in SLE, it may not suggest thatthese patients represent the coexistence of SLE and acquiredbullous dermatoses.

Key words: Lupus erythematosus, systemsc, Anti-basement membrane zone anttbodtes

林麟, 靳培英, 是元甫, 桑红桂, 徐文严. SLE的水疱发疹及其与抗基底膜抗体的关系[J]. 中华皮肤科杂志, 1993, 26(2): 73-76.

LIN Lin, JIN Pei-Ying. SLE with Vesicdobnllons Erupdons and the Relationship of Anti-BMZ Antibodics to Blistering[J]. Chinese Journal of Dermatology, 1993, 26(2): 73-76.