中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (2): 91-93.

• 论著 • 上一篇    下一篇

SLE患者血液与皮损中T淋巴细胞亚群的对比研究

方春红1, 徐世正1, 张保武1, 巫山2, 尹伊由1, 熊腊元1, 周心房1   

  1. 1. 湖北医学院第一附属医院皮肤科, 武汉, 430060;
    2. 武汉生物制品研究所免疫室
  • 收稿日期:1990-10-29 修回日期:1991-01-30 出版日期:1992-04-15 发布日期:1992-04-15

Comparative study of T cell subsets of peripkeral blood and skin lesion from patients with SLE

FANG Chun-Hong1, XU Shi-Zheng1   

  1. The First Affiliated Hospital, Hubei Medical Colllege, Wuhan, 430060
  • Received:1990-10-29 Revised:1991-01-30 Online:1992-04-15 Published:1992-04-15

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摘要： 应用抗T琳巴细胞单克隆抗体、过氧化物酶—抗酶(PAP)技术,同时观察了19例SLE患者(活动期11例,缓解期8例)血液及皮损内T细胞亚群的变化.结果表明.①SLE患者皮损中T细胞亚群变异范围大.T4+与T8+细胞数目接近,以T8+细胞稍占优势.T3+及T8+;明显高于对照组,活动期与缓解期则无明显差异.②SLE患者血液中T细胞亚群数目明显减少.⑧活动荆患者血液T4/T8比值较对照组明显为高,缓解期患者则无明显差异.SLE患者皮损中T4/T8比值低于对照组.④SLE患者血中T细胞数目减少的同时,皮损中T细胞数明显增加,恰与对照组相反.提示SLE患者的血液中T细胞减少与T细胞在皮肤等组织中消耗有一定关系.

关键词: 红斑狼疮,全身性, T淋巴细胞

Abstract: T cell subsets of peripheral blood and skin lesion from 19 patients with SLE,ineluding 11 active and 8 inactive, were simultaneously observed using anti-T cell monoclonal antibodies and pcroxidase antiperoxidase technique.

Key words: Lupus erythettsatosus,systemic, T lymphocytes