中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (2): 77-79.

• 论著 • 上一篇    下一篇

尖锐湿疣患者皮损中人乳头瘤病毒核酸检测分析

赖晃文1, 唐赓云1, 宋玉芳1, 王达富2, 杨慧兰2, 冯穗一2   

  1. 1. 广州军区广州总医院电镜室, 510010;
    2. 广州军区广州总医院皮肤科, 510010
  • 收稿日期:1990-12-04 修回日期:1991-06-16 出版日期:1992-04-15 发布日期:1992-04-15

Detection of human papilloma virus DNA sequences in condyloma acuminata

LAI Huang-Wen1, TANG Geng-Yun1   

  1. Laboratory of Electron Microscope, General Hospital of Guangzhou Unit of PLA, Guangzhou, 510010
  • Received:1990-12-04 Revised:1991-06-16 Online:1992-04-15 Published:1992-04-15

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摘要： 应用HPV6b,HPV11,HPV16和HPV18型DNA探针,对48例生殖器尖锐湿疣和15例正常宫颈组织进行核酸序列检测.结果:尖锐湿疣HPY各型总阳性例数为42例(87.5%),而正常宫颈组织HPV各型均阴性,尖锐湿疣HPV6b,11,16,18型探针检出率分别为68.8%,79.2%,43.8%,14.6%,提示本组病例以HPV11和HPV6b型感染为主.男女性患者各型探针阳性率基本相近.并发现本组病例以二型以上混合感染多见.

关键词: 乳头状瘤病毒, 尖锐湿疣, DNA探针, 杂交

Abstract: Forty-eight biopsies from genital condyloma acuminata were examined for the presenca of human papilloma virus ( HPV)DNA sequences by dot blot hybridization with HPY-6b,HPV-11,HPV-16 and HPV-18 DNA probes. The results showed that 42 of 48 cases wets positive for HPV DNA sequences (87.56%). Among them,thc detective rates of HPV-6b,HPV-11,HPV-16 and HPV-18 DNA squenoea wore 68.8%.79.2%,43.8% and 14.6%,respectively.

Key words: Papillomavliuses, Condylomata acuminnta, DNA probe, Hybridizaytion