中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (6): 372-374.

• 论著 • 上一篇    下一篇

抗体分泌细胞与SLE临床关系的研究

杜振波, 刘荣卿, 叶庆佾, 唐书谦   

  1. 第三军医大学第一附属医院皮肤科, 重庆 630038
  • 收稿日期:1990-08-16 修回日期:1991-01-03 出版日期:1991-12-15 发布日期:1991-12-15

Reiation of Antibody Secreting Cells(ASC) and Clinical Disease Activity in Systemic Lupus Erythematosus

DU Zhen-Bo, LIU Rong-Qing   

  1. The First Teaching Hospital, Third Military Medical University Chongqing
  • Received:1990-08-16 Revised:1991-01-03 Online:1991-12-15 Published:1991-12-15

PDF (PC)

482

赞

摘要： 用免疫酶斑技术检测30例SLE患者和19例正常人抗体分泌细胞(ASC),结果表明SLE患者ASC明显升高,ASC数目与疾病活动、肾损害及其它反映病情活动性指标相关.作者认为ASC升高提示SLE患者外周血异常活化B细胞增多,检侧ASG可用于评价疾病的活动性.

关键词: 过敏原, 点刺试验, 阿罗格, 过敏性疾病

Abstract: Peripheral blood lymphocytes actively secreting immunojlobulin G(IgG) were quantitated in 30 patients with systemic lupus crythematasus(SLE) and compared with the number of such antibody secreting cells(ASC) in 19 norxnal controls using Elispot assay.The results showed that the number of IgG-ASC in patients with SLE was significantly higher than that in normal controls.The number of IgG-ASC correlated with disease activity,renal involvement and serologic features.The results confirmed that the number of 13 cells with hyperactivity increased in patients with SLE.The anthars suggest that IgG-ASC may be used as a useful indicator for the disease activity of SLE.