中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (6): 369-371.

• 论著 • 上一篇    下一篇

52例尖锐湿疣组织病理及免疫组化研究

孙建方1, 刘季和1, 是元甫1, 桑红桂1, 叶干运2   

  1. 1. 中国医学科学院皮肤病研究所, 南京 210042;
    2. 指导者
  • 收稿日期:1990-07-05 修回日期:1991-01-05 出版日期:1991-12-15 发布日期:1991-12-15

Histopathological and Immunohistochemical Study on Fifty-two Case of Condyloma Acuminatum

SUN Jian-Fang1, LIU Ji-He1   

  • Received:1990-07-05 Revised:1991-01-05 Online:1991-12-15 Published:1991-12-15

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摘要： 对52例尖锐湿疣患者进行组织病理及免疫组化的研究,结果表明94%的尖锐湿疣损害组织病理检查具有特征性的空饱化细胞,但未见空饱化细胞不能除外尖锐湿疣的诊断.抗乳头瘤病毒抗原PAP免疫组化检测,阳性率为67.3%0同时发现中重度空泡化细胞,其免疫组化阳性检出率高于轻度空泡化细胞,表明前者含有较多的成熟病毒颗粒,可能是病毒感染的后期结果.

Abstract: In this paper,fifty-two cases of condyloma acuminatum(CA) were studied histopathologically and immunohistochemically.The result of histopathologieal cxsatnination showed that rite characteristic changes of vaculnated cells(koilocytes) could be found in 94%,of the sections.But their absence did not rule out the possibility of CA.With the anti-PV-Ag PAP immunohistochemical technique,the positive gate of PV-Ag was 67.3%.In the same time,the positive rate of immunochemical study was higher in the moderately and severely vacuol aced cells than those in the mildly vacuolated which indicated that the former contained more mature viral panicles and might be the advanced effects of the vital infection.