中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (6): 366-368.

• 论著 • 上一篇    下一篇

硬红斑免疫病理研究

米庆胜, 陈明   

  1. 第二军医大学长海医院皮肤科, 上海 200433
  • 收稿日期:1990-07-11 修回日期:1991-03-14 出版日期:1991-12-15 发布日期:1991-12-15

Study on the Immunopathology of Erythema Induratum

MI Qing-Sheng, CHEN Ming   

  1. Changhai Hospital, Second Military Medical University, Shanghai
  • Received:1990-07-11 Revised:1991-03-14 Online:1991-12-15 Published:1991-12-15

PDF (PC)

260

赞

摘要： 应用直接免疫荧光(DIF)及ABC免疫组化方法观察了21例硬红斑(EI)皮损中3种组织沉积免疫复合物(TIC)及S100蛋白阳性组织细胞.DIF检查显示19例EI皮损血管壁或周围有TIC沉积且以TIC-IgM为主,S100抗体ABC免痊组化显示所有EI皮狈真皮深部及皮下淋巴细胞浸润区均有S100蛋白阳性组织细胞,其数缺与皮损时期有关.本文结果提示,EI是免疫复合物型血管炎,Ⅲ型及Ⅳ型变态反应在EI发病机理解中起重要的作用.

关键词: 肿瘤坏死因子α, 核因子- kappa B, p38丝裂原活化蛋白激酶, HB-13, HP-13

Abstract: In this paper,three kinds of tissue deposits of immunr complexes(TIC) and the S100 protein positive histiocytes were investigated in the lesions of 21 patients with erythema induratum(EI) using DIF and ABC immuno-histochemical method.DIF showed that TIC were deposited on or around the blood vessel walls in 19 patients and mainly were TIC IgM.ABC immunohistochemistry showed that the S100 positive histiocytcs were present in the lymphohistocytic infiltrates of the deep dermis and subcutaneous layer in all patients and its cmunhcr was related to the duration of lesions.These results suggest that EI is an immune complex type vasculitis,and type Ⅲ and Ⅳ hypersensitivity play important roles in the pathogencsis of EI.