中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (5): 325-327.

• 论著 • 上一篇    下一篇

遗传过敏性皮炎患者NK细胞活力及IL2对其调节作用

钱起丰, 康克非   

  1. 上海医科大学皮肤病学研究所
  • 收稿日期:1988-08-21 修回日期:1989-12-23 发布日期:1990-10-15

Natural kilter cell activity and immunoregulatory effect of in effect of interleukin 2 in atopic dermatiris

QIAN Qi-Feng, KANG Ke-Fei   

  1. Institute of Dermatology, Shanghai Medical University
  • Received:1988-08-21 Revised:1989-12-23 Published:1990-10-15

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摘要： 3H-TdR细胞毒释放法检测了62例遗传过敏性皮炎(AD)患者(其中PAD13例,ADR22例,ADI9例,人DRI18例)NK细胞活性.结果表明,AD患者的NK细胞活性低于正常人(P<0.002>.在AD的分型观察中,PAD及ADR两型患者NK细胞活性显著降低(分别为P>0.01及P><0.05), ADI及ADRI两型患者NK细胞活性无明显改变(P>0.05).将正常人和AD患者单个核细胞分别用IL2处理后,观察IL2对NK细胞调节作用,结果示IL2可增强正常人NK细胞活性(P>=0.01).但不能增强AD患者NK细胞活性(P>0.5),甚至出现诱导抑制反应.AD患者NK细胞活性低下可能与免痊调节机能障碍有关.

Abstract: The NK cell activity from 62 patients with atopic dermatitis(AD) [among them 13 pure AD (PAD)，22 AD associated with respiratory allergy (ADR), 9 AD associated with icthyosis (ADT) and 18 AD associated with respiratory allergy and icthyosis (ADRI)] was determined by 3H-tlrymidine release cytotoxLcity assay.