中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (5): 291-293.

• 论著 •    下一篇

大疱性类天疱疮抗原分子异质性

朱学骏1, Yayoi Niimi2, Jean-Claude Bystryn2   

  1. 1. 北京医科大学第一医院;
    2. 纽约大学医学院
  • 收稿日期:1989-06-28 修回日期:1989-12-11 发布日期:1990-10-15

Molecular heterogeneity of bullous pernhhigoid antigens

ZHU Xue-Jun1, Yayoi Niimi2, Bystryn J-G2   

  1. The First Hospital, Beijing Medical University,Yayoi Niimi Jean-Claude Bystryn, Deft. Of Dermatology, NY University Medical Center
  • Received:1989-06-28 Revised:1989-12-11 Published:1990-10-15

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摘要： 作者应用免疫印迹技术对20例大疱性类天疱疮(BP)患者血清与表皮浸出物的反应结果作了分析,发现90%(08/20)患者血清与230KD蛋自质分子结合,25%(5/20)患者血清与160KD分子结合,其中3例同时与230KD分子结合.文章分析了160KD分子并非230KD蛋白质分子的分解产物.这个结果进一步证实了BP抗原分子具有异质性,230KD分子为BP主要抗原,绝大多数患者血清中有针对北抗原的抗体,160KD分子则为BP次要杭原,仅少数患者血清中有针对此抗原的抗体.

Abstract: Using Western immunoblot technique, 20 BP sera were reacted with epidermal extract of normal human skin. The results showed that 18 out of 20 sera (90%) combined with a 230 KD MW protein, 5 out of 20 sera (25%) combined with a 160 KD MW protein, including 3 sera also combined with the 230 KD MW protein. Theauthors hold that the 160KDMW protein is not the break down product of the 230KD MW protein. Thi s result further indicates that BP antigens are of heterogeneity. The major BP antigen is a 230 KD MW protein. Antibodies to this antigen arc present in the majority of patients with BP. The minor BP antigen is a 160 KD MW protein. About 25% of BP patients have antibody against this antigen.