中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (4): 222-223.

• 论著 • 上一篇    下一篇

Paget病的免疫组织化学研究

高钟禹1, 张紫萱2, 王维屏3, 张传森1   

  1. 1. 山东省千佛山医院病理科;
    2. 山东医科大学病理解剖教研室;
    3. 山东省立医院病理科
  • 收稿日期:1988-12-27 修回日期:1989-05-04 出版日期:1990-08-15 发布日期:1990-08-15

Innmunohistochemcal study of Paget’s disease

GAO Zhong-Yu1, ZHANG Zi-Xuan2   

  1. Shangdong Qianfushan Hospiital
  • Received:1988-12-27 Revised:1989-05-04 Online:1990-08-15 Published:1990-08-15

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摘要： 应用免疫过氧化物酶技术研究18例Paget病(PD),14例发生于乳头、4例货生于乳房外.使用的抗体为抗癌胚抗原、抗上皮膜抗原及抗S100蛋白扰体.全部病例癌胚执原(CAA)及上皮膜抗原(EMA)均为阳性.S100蛋白见于6例Paget细胞.我们的观察证实Paget细胞为腺癌细胞.PD发生的机制通常认为由其下的癌扩展而来,但在某些病例(特别是乳房外PD)不能排除由丧皮内的原始干细胞发生的可能性.

Abstract: Eighteen casts of Paget's disease-14 of them involved nipples, and 4 were extramamnnary were studied using the immunoperaxidase technique. The antiuodies used were directed against CEA, EMA and S100 protein. All cases were positive for anti-CEA serum and monoclonal anti-EMA antibody.