中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (3): 153-155.

• 论著 • 上一篇    下一篇

32例皮肤T细胞淋巴瘤外周血染色体分析

方丽, 包忠刚   

  1. 上海医科大学皮肤病学研究所
  • 收稿日期:1988-10-04 修回日期:1989-05-02 出版日期:1990-06-15 发布日期:1990-06-15

CHROMOSOME STUDY OF BLOOD CELL IN 32 PATTENTS WITH CUTANEOUS T CELL LYMPHOMA

FANG Li, BAO Zhong-Gang   

  1. Dermatology Institute of Shanghai Medical University
  • Received:1988-10-04 Revised:1989-05-02 Online:1990-06-15 Published:1990-06-15

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摘要： 报告32例皮肤T细胞淋巴瘤(CTCL)患者外周血染色体分析。MF23例、非向表皮性T细胞琳巴瘤8例、Sézary综合征1例。其中26例外周血细胞有异常核型,受检细胞共320个,有异常核型为48个(15%)。结构畸变略多于数量畸变,前者主要表现为染色体缺失,后者主要表现为非整倍体。畸变率与CTCL之类型、病期及皮损范围无明显关联,但在MF肿瘤期畸变率显著升高,提示染色体崎变与病情、预后有一定关联。

Abstract: Karyotypic analysis of the peripheral blood cell in 32 patients with cutaneous T cell lymphoma (CTCL) was studied. Among them,there were mycosis fungoides (MF) 23 cases,non epidermotropic cutaneous T cell lymphoma (NCTCL) 8 cases, Sézary syndrome (SS) 1 case. 26 cases had abnormal karyotypes including structural and quantitative aberration. Chromosome deletion and aneuploidy were found mainly. There was no relationship between the aberration and the type of CTGL,duration of the disease and the size of lesions. But aberration rate in MF tumor stage waa higher than in pre-tumor stage. It suggests chromosome aberration may be related to the severity and prognosis of CTCL.