中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (2): 75-78.

• 论著 •    下一篇

应用杭中间丝抗体免疫组化法检测皮肤肿瘤

伍津津, 刘荣卿, 唐书谦, 叶庆佾, 钟白玉   

  1. 第三军医大学一附院皮肤科
  • 收稿日期:1988-07-09 修回日期:1988-09-27 出版日期:1990-04-15 发布日期:1990-04-15

IMMUNOHISTOCHEMICAI. STUDY IN THE CUFANEOUS TUMORS: USINGANTI-INTERMEDIATE FILAIMENT ANIBODIE

WU Jin-Jin, LIU Rong-Qing   

  1. The First Teaching Hospital, Third Military Medical University
  • Received:1988-07-09 Revised:1988-09-27 Online:1990-04-15 Published:1990-04-15

摘要: 本文选用5种抗中间丝抗体和两种相关的肿瘤标记抗体,采用ABC免疫组化染色技术对22例皮肤恶性肿瘤,33例皮肤良性肿瘤和12例其它上皮肿瘤的冰冻切片进行染色.结果显示:1.中间丝分类法在皮肤肿瘤病理中能作为辅助诊断工具,确定组织的起源,为皮肤肿瘤的诊断和鉴别诊断提供依据,尤其是在诊断黑素瘤和转移性肿瘤中意义较大.2.抗不同分子量角蛋白抗体的应用,可帮助区分鳞癌、腺癌等,还可探测癌细胞浸润的深度,对指导临床治疗和估计预后有一定意义.

Abstract: Anti-intermediate. filament antibodies including monoclonal antibodies to keratin (CAM5.2, AF2), vimentin, desmin and polyclonal antibody to keratin as well as antibodies to CEA and S100 protein were tested on fresh frozen sections of 22 cascs of malignant cutaneous tumors, 33 cases of benign cutaneous tumors and 12 cases of other epithelial tumors by ABC immunohistochemical method in this article.