中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (1): 15-18.

• 论著 • 上一篇    下一篇

60例皮肤恶性淋巴瘤病人血清抗HTLV抗体的意义

康克非1, H. Peralta2, 丁铁刚1, 翁孟武1, 邱丙森1, B. Safai2   

  1. 1. 上海医科大学皮肤病学研究所;
    2. 美国组约Slaorr-Kettering癌症研究中心皮肤科
  • 收稿日期:1988-06-02 修回日期:1988-08-26 出版日期:1990-02-15 发布日期:1990-02-15

THE SIGNIFICANCE OF ANTI-HTLV ANTIBODIES IN THE SERA OF 60 CASES OF PATIENTS WITH MALIGNANT LYMPHOMA

KANG Ke-Fei1   

  1. Institute of Dermatology, Shanghai Medical University
  • Received:1988-06-02 Revised:1988-08-26 Online:1990-02-15 Published:1990-02-15

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摘要： 本文对58例皮肤T细胞淋巴瘤(CTCL)[其中56例为蕈样肉芽肿(MF),2例为非向表皮性CTCL]和2例皮肤B细胞淋巴痕(CBCL)免疫印迹法检测HTLV-Ⅰ和HTLV-Ⅲ,抗体,总阳性率为26.7%(16/60) 其中HTLV-I p24抗体占5%(3/60,1例CBCL),其余主要为HTLV-ⅢP64抗体占18.3%,除1例MF尚合并HTLV-ⅢP41,抗HTLV抗体成分均为单独出现.

Abstract: Anti-HTLV-Ⅰ and HTLV-Ⅲ antibodies were petected by using Western blot analysis in 58 cases of cutaueous T-cell lymphoma (CTLC) including 56 cases of mycosis fungoides (MF) and 2 cases of non-epirlermotropic CTCL,and 2 cases of cutaneous B cell lymphoma.The total positivity of the antibodies to HTLV was 26.7% (16/60).5%(3/60) of the case(among them CBCL 1 case) had anti-HTLV-Ⅰ p24 antibody,the other (18.3%) had mainly HTLV-Ⅲ p64 antibody.Except in one case of MF had both anti-HTLV-Ⅲ p64 and p41 antibodies,and other patients had only one anti-HTLV atxtibody.The results suggested that CTCL may have its own etiological virus and its antibody showed partial cross-reactivity with other HTLV virus.