中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (5): 306-308.

• 论著 • 上一篇    下一篇

乳房外湿疹样癌超微结构观察——冷冻蚀刻方法

邹铭西1, 张京1, 鲁崎唔2   

  1. 1. 中日友好医院皮肤科;
    2. 中国科学院生物物理研究所六室
  • 收稿日期:1988-03-15 修回日期:1988-08-13 出版日期:1989-10-15 发布日期:1989-10-15

Ulstrastructural observation of extramammary Paget disease-freeze-etching technique

Z0U Ming-Xi1   

  1. China-Japan Friendship Hospital, Beijing
  • Received:1988-03-15 Revised:1988-08-13 Online:1989-10-15 Published:1989-10-15

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摘要： 本文报告3例阴囊阴茎部位的乳房外湿疹样癌,经组织病理学证实均为浸润癌.用冷冻蚀刻方法观察Paget细胞及浆膜超微结构.特点是Paget细胞大,核圆形或椭圆形,核膜略呈波纹状,胞浆内有较丰富的高尔基复合体、内质网,偶见较大的线粒体,有空泡形成,缺乏张力丝.邻接的Paget细胞间隙内有微绒毛及泡状结构多Paget细胞之间及角航细胞与Paget细胞间未见裂隙连接,偶见桥粒;而邻近的角航细胞之间则有正常桥粒及较正常皮肤稍多的裂隙连接.

Abstract: Three cases of extramammary Paget disease of the scrotum and penis were reported. Histopathologically, they were confirmed as infiltrating carcinoma, Ultrastructures of Paget cells and their plasma membranes were observed by freezeetching electron microscopy.The Paget cells are characterized by larger cells with round or oval nuclei enclosed by a slightly undulated nuclear membrance. They include abundant cytoplasmic Golgi appasatus, endoplasmic reticulum, occasionally larger mitochondria and vacuoles, but lack of tonofilaments. The microvilli and vesicles were seen in the inercellular spaces between two Paget cells. No ga.p junction were found between two Paget cells as well as between Paget cells and adjacent keratinocytes, occasionally desmosomes were observed. While more gap junctions than that in normal skin and normal desmosomes were found between two adjacent keratinocytes.