中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (3): 150-152.

• 论著 • 上一篇    下一篇

SLE患者血清抑制NK活性的探讨

王长安1, 朱亚忠2, 马安伦1, 张冬青1, 李培成3, 朱伦健4, 徐惠珍4, 陈泽仪4   

  1. 1. 上海市免疫学研究所;
    2. 上海第二医科大学新华医院儿研所;
    3. 上海中医学院龙华医院中心实脸室;
    4. 上海第二医科大学瑞金医院免疫室
  • 收稿日期:1988-01-18 修回日期:1988-05-30 出版日期:1989-06-15 发布日期:1989-06-15

STUDIES OF SLE PATIENTS SERA IN-HIBITION ON NK ACTIVITY OF NORMAL INDIVIDUAL

WANG Chang-An1, ZHU Ya-Zhong2   

  1. Shanghai Institute of Immunology
  • Received:1988-01-18 Revised:1988-05-30 Online:1989-06-15 Published:1989-06-15

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摘要： 本文报导了SLE患者的天然杀伤细胞(NK)活性及血清抑制作用。25例SLE患者与正常个体的NK活性相比较,M±S分别为10.79±7,34%及32.69±9.46% (P<0.001).16例及19例SLE病人血清分别处理正常人单一核细胞(MNC)4及20小时,然后测定NK活性,我们发现血清抑制NK活性百分比分别平均为37.67±12.99%及88.88±8.1%。病人血清的免疫复合物(IC)与血清抑制无关。其他如血清中的PGE2水平及抗淋巴细胞抗体(ALA)亦与NK活性无关。我们发现SLE病人血清明显地抑制正常人单一核细胞的NK活性,从而支持了血清因素降低NK活性的结论。

Abstract: This article reports the NK cell activity and serum inhibition studies in SLE patients. When the NK activity of 25 SLE patients were compared with the NK activity in the age-and sex-matched controls, the results of NK activity were 10.79±7.34% and 32.69±9.46% respectively (P<0.001). Patients sera inhibition test was investigated. When the peripheral blood MNC of normal subjects were treated with 16 SLE sera for 4h, and were treated with 19 SLE sera for 20h before determining the NK activity, we found that the percentage of NK activity inhibited was 37.67±12.99% and 88.88±8.1% respectively. No correlations were observed between circulating immune complexes (IC) in SLE and sera inhibition. Other clinical parameters, such as PGE2 level of sera and anti-lymphocyte antibodies (ALA) also did not correlate with NK activity. We found that sera from SLE patients markedly inhibited the NK activity of normal MNC. Our data support the concept that serum factors in SLE patients reduce NK activity.