中华皮肤科杂志 ›› 1988, Vol. 21 ›› Issue (5): 291-292.

• 论著 • 上一篇    下一篇

0.05%CGP14 458软膏治疗银屑病的疗效及其对肾上腺功能的影响

胡兹嘉1, 靳培英1, 岳晓玉1, 邵长庚1, 叶干运1, S. J. Yawalkar2   

  1. 1. 中国医学科学院皮肤病研究所;
    2. 瑞士Ciba-Geigy有限公司医学部
  • 收稿日期:1987-11-20 修回日期:1988-02-25 出版日期:1988-10-15 发布日期:1988-10-15

TREATMENT OF PSORIASIS WITH 0.05% CGP14 458 OINTMENT：OBSERVATIOIV OF CLINICAL EFFECT AND PLASMA CORTICOSTEROID LEVELS

HU Zi-Jia1, JIN Pei-Ying1   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing
  • Received:1987-11-20 Revised:1988-02-25 Online:1988-10-15 Published:1988-10-15

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摘要： 0.05% CGP14 458是一种新的外用强效皮质类固醇制剂.本研究用CGP治疗13例银屑病住院患者,所有病人在3周内达到治愈和显著进步.血浆皮质醇测定显示在封包期间显著降低(P<0.01).研究表明如果皮损面积限制在20%体表面积以下,每周剂量小于60g,每日2次涂患处是安全有效的,封包不宜作常规使用.

Abstract: 0.05% CGP 14 458 is one of the new potent topical corticosteroids. Thirteen psoriasis inpatients were treated with CGP. All the the patients were cured or markedly improved within 3 weeks. The determination of serum cortisol levels showed that during the period of occlusive application the levels significantly decreased (P<0.01).This study indicated that, if the extent of skin involvement was less than 20% of body surface aria and the dose of CGP was less than 60g weekly, the regimen of topical application of CGP twice daily for 3 weeks may be considered to be safe and eflective. The occlusive therapy should not be used as a routine.