中华皮肤科杂志 ›› 1988, Vol. 21 ›› Issue (5): 283-285.

• 论著 • 上一篇    下一篇

天疱疮、类天疱疮自身抗体检测的临床意义

刁庆春, 刘荣卿, 唐书谦   

  1. 第三军医大学附一院皮肤科
  • 收稿日期:1987-06-04 修回日期:1987-11-30 出版日期:1988-10-15 发布日期:1988-10-15

DETERMINATION OF AUTOANTIBODIES IN PEMPHIGUS AND PEMPHIGOID

DIAO Qing-Chun, LIU Rong-Qing   

  1. The First Affliated, The Third Mitilary Medical College, Chongqing
  • Received:1987-06-04 Revised:1987-11-30 Online:1988-10-15 Published:1988-10-15

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摘要： 作者用间接和直接免疫荧光法检测了23例天疱疮和15例类天疱疮病人血中和皮肤中的自身抗体,并结合临床进行了连续观察.根据检查结果,作者认为:1.间接免疫荧光(IIF)法检查血清天疱疮抗体(PAb)对天疱疮诊断有重要价值,PAb滴度及其变化可作为判断病情活动度及其变化的参考指标,并对指导怡疗有一定参考意义.2.IIF法检查血清基底膜带(BMZ)抗体对大疱性类天疱疮(BP)病人诊断有参考价值,BMZ抗体滴度与病情活动度相关不显著.3.皮损及“正常”皮肤直接免疫荧光(DIF)检查对天疱疮和类天疱疮有诊断价值,“正常”皮肤DIF检查对监察病情有一定意义.

Abstract: In this article, autoantibodies in sera and skin of 23 patients with pemphigus and 15 patients with pemphigoid are surveyed by indirect and direct immunofluorescent tests. According to the results, the authors considered that: 1. The determination of circulating pempniigus antibodies (PAb) with indirect immunofluorescence (IIF)is of diagnostic value for pemphigus. The level of PAb titer and its variation can be used to evaluate the disease activity, and also as a parameter in the treatwent of pemphigus.