中华皮肤科杂志 ›› 1988, Vol. 21 ›› Issue (5): 276-279.

• 论著 • 上一篇    下一篇

成人与儿童线状IgA大疱病的比较观察

靳培英, 是元甫   

  1. 中国医学科学院皮肤病研究所
  • 收稿日期:1987-11-20 修回日期:1988-02-09 出版日期:1988-10-15 发布日期:1988-10-15

LINEAR IgA BULLOUS DERMATOSIS IN ADULT AND CHILDREN：THE OBSERVATION ON CLINICAL, PATHOLOGICAL AND IMMUNOPATHOLOGICAL STUDY

SIN Pei-Ying, SHI Yuan-Fu   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing
  • Received:1987-11-20 Revised:1988-02-09 Online:1988-10-15 Published:1988-10-15

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摘要： 本文对免疫病理表现有线状IgA沉积在BMZ的24例患者(成人18例、儿童6例)进行了临床、病理与免疫病理的分析观察,发现成人与儿童在临床症状、皮损形态与分布以及免疫病理等方面均有不同之处,说明成人与儿童线状IgA大疱病是线状IgA大疱病病谱中的两个分立疾患.本文也对免疫球蛋白在BMZ的沉积型进行了分析,发现除了线状沉积外,其中有2例成人的沉积型为颗粒状线状,而且既沉积在BMZ,也沉积在真皮乳头.认为这两例应考虑为(DH)与(BP)的混合型.另1例呈颗粒状线状沉积在BMZ,考虑为IgA BP.

Abstract: The purpose of the study is to make tomparison between 18 adults and 6 children patients with linear IgA bullous dermatosis in the clinical feature, immunopathology, etc. The results of this study revealed that linear IgA disease of adults (LADA) is different from the benign chronic bullous dermatosis of childhood (BCBDC)in the mode of onset, the site of predilection, the pattern of lesions, etc. For this reason, BGBDC, LADA and cicatricial pemphigoid (CP) are distinct entities respectively in the spectrum of linear IgA dermatosis.