中华皮肤科杂志 ›› 1988, Vol. 21 ›› Issue (4): 210-212.

• 论著 • 上一篇    下一篇

直接免疫荧光检查在诊断及鉴别硬皮病与混合结缔组织病上的应用

王洪琛, 邵燕苓, 苑勰, 阎红   

  1. 北京协和医院皮肤科
  • 收稿日期:1987-04-01 修回日期:1987-05-18 出版日期:1988-08-15 发布日期:1988-08-15

DIF study in the diagnosis and differential diagnosis between MCTD and PSS

Wang Hong-chen, Shao Yan-ling   

  1. The Peking Union Medical College Hospital, Beijing
  • Received:1987-04-01 Revised:1987-05-18 Online:1988-08-15 Published:1988-08-15

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摘要： 50例PSS、10例MCTD患者前臂伸侧皮肤活检DIF检查发现:10%PSS与60% MCTD出现有表皮细胞核Ig着色,MCTD均为IgG大斑点型,PSS则以均质为主,无1例为IgG大斑点型.10%PSS与30%MCTD患者BMZ出现Ig带状沉积.作者结论为:(1)在患有手部皮肤不典型硬化、雷诺氏现象、关节炎的患者,若DIF出现表皮细胞核大斑点IgG着色,即可诊断为MCTD.(2)BMZ带状Ig沉积不能做为区分二者的主要依据.

Abstract: DIF studies on skin biopsy specimens taken from the extensor surface of forearms of 50 patients with PSS and 10 patients with MCTD were carried out. Epidermal nuclear immunoglobulin deposition was observed in 10% of PSS and 60% of MCTD. The immuno-fluorescent epidermal nuclear staining pattern in patients with MCTD were speckled and the majority of the patients with PSS were homogeneous with none of them was speckled. A positive immunoflourescent band form deposition of immunoglobulins was found along the BMZ in 10% of patients with PSS and 30% of patients with MCTD. The authors discussed the findings in detail and concluded as following: 1. When a patient has sclerosing skin changes (or swelling) of the hands, Raynaud's phenomenon, polyarthritis (or arthral-gia) and shows a speckled epidermal nuclear IgG staining in DIF simultaneously, the diagnosis of MCTD can be established. 2. A positive immunoflourescent band test by DIF is not specific for the diagnosis of MCTD and thus cannot be used as a means to difFerentiate MCTD from PSS.