中华皮肤科杂志 ›› 1988, Vol. 21 ›› Issue (1): 8-10.

• 论著 • 上一篇    下一篇

Ro、La抗原的部分生物学特性

张建中, 马圣清, 王光超   

  1. 北京医科大学第一医院皮肤科
  • 收稿日期:1986-09-07 修回日期:1987-06-05 发布日期:1988-02-15

EIOLGIGAL CHARAGTERIZATION OF RO AND ANTIGENS

Zhang Jiangzhong, Ma Shengqing   

  1. The First Hospital of Beijing, Medical University, Beijing
  • Received:1986-09-07 Revised:1987-06-05 Published:1988-02-15

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摘要： 本文对Ro,La抗原的一些生物学特性进行了研究.在哺乳类动物(犬、小牛、猪、兔及豚鼠)和人组织中的Ro,La抗原较易测得,而大鼠和小鼠中的Ro,La抗原则不易测得,说明Ro,La抗原在种系间存在量的差异.Ro,La抗原广泛存在于人体各组织器官中,是细胞的基本成分,但在不同组织及器官中的分布不均匀,且这种分布与临床上SLE病人的器官受累频率无一致性.以人胎肝为底物进行间接免疫荧光检查时,Ro抗原主要表现为胞浆内荧光,而以大鼠、小鼠肝为底物时则为阴性,La抗原在人胎肝印片中表现为较强的胞浆和胞核(均质型)染色,而在大鼠和小鼠肝中则表现为较弱的粗斑点线型核荧光,表明在不同的哺乳动物中,抗原可能还存在部位的差别.

Abstract: Some biological characteristics of Ro and La antigens were investigated. Ro and La anti fens were easily detected in human, dote, calf,pig, guinea pig and rabbit tissues but not in rat and moose tissues, suggesting that the quantity of Ro and La antigens varied in different mammalian cells. These antigens, existing not in almcst all tissues of the human body, are not tissue or organ-specific.