中华皮肤科杂志 ›› 1987, Vol. 20 ›› Issue (6): 343-345.

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甲下黑素瘤

杨景春, 苏肖汉, 杨次颖, 黄苏, 侯桂春   

  1. 中国医科大学附属一院皮肤科
  • 收稿日期:1986-10-30 修回日期:1987-03-26 出版日期:1987-12-15 发布日期:1987-12-15

Subungual melanoma

Yang Jingchun   

  • Received:1986-10-30 Revised:1987-03-26 Online:1987-12-15 Published:1987-12-15

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摘要： 本文就甲下黑素瘤(SM)7例进行了临床、组织病理和电镜观察.5例为指甲,2例为趾甲,5例为拇指(趾)甲(左3,右2).4例先于甲板出现纵行黑线,黑线出现平均年龄47.6岁,从黑线至SM形成平均为7.3年,为了预防SM应早期切除黑线.瘤细胞以大上皮样细胞为多,3/7例呈多形细胞混合存在,有的瘤细胞呈印戒状,有的呈镜影状.对1例截指纵切和横切,肉眼和光镜观察证明SM始发于甲根部甲母的黑素细胞.电镜观察3例见到黑素体,直径为0.16-1.0μ,见到巨大黑素体、黑素体复合体和病毒颗粒样黑素体.

Abstract: In this paper, the clinical, histopathological and electron microscopic observations are made in 7 cases of subungual melanoma (SM).In 5 cases SM were found in the finger nails and 2 in the toe nails, and 5 in the thumb or great toe nails (2 on the right, 3 left). Longitudinal black lines developed in the nail plate before the appearance of SM in 4 cases. The mean age of the occurrance of the black lines was 47.6 years, and the mean time from the occurrence of black lines to the SM formation was 7.3 years. Thus, early excision of the black lines should be performed to prevent the devlopment of SM. Most of the tumor cells were, large epithelioid cells, and in 3/7 of cases polymorphous cells were also observed.