中华皮肤科杂志 ›› 1987, Vol. 20 ›› Issue (5): 264-266.

• 论著 • 上一篇    下一篇

同卵双生深在性红斑狼疮

范廉洁1, 汪秀明2, 钟慧平2, 宋玉如1, 李广第3   

  1. 1. 北京中日友好医院皮肤科;
    2. 北京中日友好医院临床医学研究所;
    3. 中国原子能科学研究院职工医院皮肤科
  • 收稿日期:1986-09-02 修回日期:1986-11-17 出版日期:1987-10-15 发布日期:1987-10-15

Lupus erythematosus profundus in homozygous twin sisters

Fan Lianjie1   

  • Received:1986-09-02 Revised:1986-11-17 Online:1987-10-15 Published:1987-10-15

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摘要： 本文报告一对双生姐妹儿乎同时在类似部位发生经临床及病理证实的LEP.其血型、HLA分型完全一致.经计算其同卵概率为98.87%,故认为系同卵双生,并认为遗传因素在发病上起一定作用.两位患者血内均测得同一型别的抗血管内皮细胞抗体,并对此种抗体的可能作用进行了讨论.

Abstract: This paper reports a pair of twin sisters who developed nearly in the same time, on the same location of the body lesions of lupus ery-thematosus profundus which were identified by the clinical features and histopathogical findings. Their blood group and HLA typing were completely identical. The homozygous probability was 98.87% by calculation, so it was considered that they were homozygous twins and the hereditary factor played certain role in the pathogenesis of the disease. The same type of anti-blood vessel endothelial cell antibody was found in the peripheral blood of both patients. A brief discussion was made around the possible function of this antibody.