Abstract: This article reports the clinical analysis of psychoneurological disturbances in 80 cases of SLE. The central nervous system manifestation caused by the SLE disease occurring 88.9%, indirectly 3.9%, corticosteroid 1.3%, and infection 6.2%. In the former, the psychiatric symptoms accounted for 19.7%, psychoneurological symptoms 56.3% and neurologic symptoms 24%. The psycho-neurological symptoms were multi-form. From the results of laboratory examination and other symptoms accompanied indicated that the psycho-neurological symptom was one of the active manifestation of the disease. The positive Al/TA test of CSF and abnormality of EEG were the index not only helpful to the disease but also useful for the differential diagnosis to the other cerebral diseases. The mortality rate in this series reached 48.8%, among which, about 1/3 cases died from the SLE disease itself while the others from the complications. The dosage of cortico-steroid (Prednisone or its equivalents) treated in the series was 60-80 mg/d with encouraging effect. The therapeutic effect of immunosuppressives in combination with cortico-steriods seemed better than cortico-steriod used alone.