中华皮肤科杂志 ›› 1987, Vol. 20 ›› Issue (1): 25-28.

• 论著 • 上一篇    下一篇

抗RNP抗体与结缔组织病

陈德利1, 陈集舟2, 施守义3, 杨虎天4, 王慧珍5, 王万超6, 郭伟7, 顾建中2, 沈宜洁7, 刘松林7, 朱敏1   

  1. 1. 上海铁道医学院附院皮肤科;
    2. 北京医科大学第一医院皮肤科;
    3. 上海医科大学皮肤病研究所;
    4. 上海市第一人民医院内科;
    5. 北京协和医院检验科;
    6. 上海市免疫研究所;
    7. 上海铁道医学院附院检验科
  • 收稿日期:1985-12-23 修回日期:1986-06-06 出版日期:1987-02-15 发布日期:1987-02-15

Anti-RNP antibody and connective tissue disease

Chen Deli1   

  • Received:1985-12-23 Revised:1986-06-06 Online:1987-02-15 Published:1987-02-15

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摘要： 本文报告以小牛胸腺提取物(ENA),并用被动血凝法和对流免疫电泳法,测定5家医院785例患者,分析150例抗体阳性患者的结果.抗RNP抗体在混合性结缔组织病(MCTD)中阳性率最高,为100%.该抗体也见于其他结缔组织病(CTD),偶见于非CTD,但血清效价低.高效价的抗RNP抗体有助丁MCTD的诊断,可作为该病的血清学标记.抗RNP抗体同某些临床表现相伴,可能同其发病机理有关.通过本研究,我们认为MCTD为一个独立疾病,其具有一组特征性临床表现和免疫学异常. Sharp(1983)提出的MCTD诊断标准具有一定的实用意义,值得进一步探讨.

Abstract: This article reports the analysis of 150 patients with positive anti-RNP antibody test detected among 785 patients in 5 hospitals by passive hemagglutination test combined with counterimmuno-electrophoresis with calf thymus extract (ENA). The positive rate of ant-RNP in MCTD was the highest being 100%. RNP antibody could also be found in other connective tissue diseases, occasionally in non-cosmective tissue diseases, but the titer was low. High titer of anti-RNP antibody was helpful for the diagnosis of MCTD, and regarded also to be the serological marker of this disease. The anti-RNP antibody proved to be correlated to certain clinical manifestations, also possibly related to the pathogenesis of the disease. From this study, the authors consider MCTD is a distinct disease entity with a characteristic clinical manifestations and immunologic abnormalities. The diagnostic criteria of MCTD proposed by Sharp (1983) was practical and worth while to be used and further investigated.