中华皮肤科杂志 ›› 1986, Vol. 19 ›› Issue (6): 330-332.

• 论著 • 上一篇    下一篇

环己吡酮氨乙醇对皮肤真菌病的临床与实验室观察

郑岳臣1, 许彤华1, 王曙明1, 谢建敏1, 祝兆如1, 杨泽珈2, 吴绍熙3, 吴保昌4   

  1. 1. 同济医科大学附属协和医院皮肤科;
    2. 同济医科大学临床药理研究室;
    3. 中国医学科学院皮肤病研究所真菌室;
    4. 南京市鼓楼医院皮肤科
  • 收稿日期:1985-12-23 修回日期:1986-05-26 发布日期:1986-12-15

Clinical and laboratory observation on effects of cyclopiroxolamine on dermatomycoses

Zheng Yuechen1   

  • Received:1985-12-23 Revised:1986-05-26 Published:1986-12-15

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194

摘要： 本文报告了环己吡酮氨乙醇对10种常见致病真菌的抑菌试验结果,最小抑菌浓度(MIC)为1~16μg/ml.同时报告了1%环己吡酮氨乙醇霜(Batrafen霜)治疗皮肤真菌病138例的临床与实验室观察结果.痊愈率为79%.其中体股癣疗效较好,手足癣次之.大多数在用药第1周内止痒.体股癣大多在第1周末皮损开始隐退,手足癣在第2~3周开始好转.有7.9%的病人用药后发生接触性皮炎、毛囊炎和使湿疹播散,但其间未中止治疗.除毛囊炎酌情给抗炎抗过敏治疗外,停药1~5周均自行消退.未发现全身反应.停药后随访2~12周,有23%的病例复发.

Abstract: Result of the experiment on ten strains of comon pathogenic fungi inhibited by ciclopiroxolamine was reported. The AZIQ of the drug ranged from 1-16μg/ml. One hundyed and thirty-eight patients with dermatomyroses were treated with 1% ciclopiroxolamine (Batrafen) cream, the effects were as follows: 79% (109/138) cases were cured. The effects on Tinea corporis and Tinea cruris were better than those on Tinea manuum and pedis. Pruritus of the most patients disappeared one week after treatment. The lesions of the most patients suffering from Tinea corperis and Tinea cruris began to improve one week after treatment, the lesions of patients of Tinea manuum and pedis improved 2 to 3 weeks after treatment. 11 cases experienced a variety of side effects, including contact dermatitis, folliculitis and disseminated eczema. These side effects disappeared 1-5 weeks after with-drawal of the drug. There were no systemic side reactions. These patients were followed up for 2-4 weeks after stopping the therapy, 23% of them relapsed.