Abstract: The phage group 2 type 55/71 coagulase-positive staphylococci, isolated from a 13-day-old infant with typical staphylococcal scalded skin syndrome (SSSS) produced experimental SSSS in newborn mice. In our experiment the optimal dosage of organisms was 9×10^6-7. The newborn mice 2-8 days old almost all developed experimental SSSS, and those above 12 days of age gave negative response except some inflammatory reaction, nodules or abscess at the site of inoculation. The subcutaneous route of inoculation was superior to the intraperitoneal route. The non-phage group 2 staphylococci failed to produce SSSS in mice of all age groups. Our experimentation precents a further proof to Melish' work on SSSS.