中华皮肤科杂志 ›› 1986, Vol. 19 ›› Issue (5): 265-269.

• 论著 • 上一篇    下一篇

22例SCLE临床及实验室观察

张建中, 马圣清, 景稳心, 陈集舟   

  1. 北京医科大学第一医院皮肤科
  • 收稿日期:1985-11-23 修回日期:1986-02-02 出版日期:1986-10-15 发布日期:1986-10-15

Subacute cutaneous lupus erythematosus：Clinical and laboratory analysis of 22 cases

Zhang Jianzhong   

  • Received:1985-11-23 Revised:1986-02-02 Online:1986-10-15 Published:1986-10-15

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摘要： 本文分析了22例亚急性皮肤型红斑狼疮(SC-LE)的临床及实验资料,并与以往报告的160例SLE及Sontheimer等报告的27例SCLE进行了比较.SCLE较SLE皮疹及光敏发生率高,而肾脏及中枢神经系统受累较少,同时发现SCLE的血液系统受累也较少.SCLE病人中的抗Ro(SSA)和(或)抗La(SSB)抗体阳性率为63.6%我们还发现,在SCLE中,环形红斑型肾脏及中枢神经系统受累更少,低补体血症发生率也低,而抗La(SSB)抗体及类风湿因子阳性率较高,约半数病人可以不用激素治疗,对DDS的治疗反应较好.丘疹鳞屑型则均需要激素治疗.我们认为SCLE是红斑狼疮谱中一个预后较好的亚型:而环形红斑型则为一个预后更好的SCLE亚型.

Abstract: The clinical and laboratory data of 22 cases of subacute cutaneous lupus erythematosus (SOLE) were analysed. Comparing with 160 cases of SLE and Sontheimer's 27 cases of SOLE, patients with SCLE had higher incidences of skin lesions and photosensitivity and less renal and CNS involvements. Patients with SOLE had less hematological involvement than SLE. The frequency of anti-Ro (SSA) and/or anti-La (SSB) antibodies was 63.6% in SCLE. SOLE patients with annular erythematous lesions had less renal and CNS involvements and less frequent hypocomplementemia than those with papulosquamous lesions, while the frequency of the anti-La (SSB) antibodies and rheumatoid factor were higher. Steroid therapy was not used in about half of the patients with annular erythematous lesion, because they responded well to the treatment of DDS. On the other hand, all patients with papulosquamous lesions required steroid therapy. We consider that SOLE is a subset in LE spectrum with good prognosis and cases with annular erythematous lesions are a milder subset of SOLE.