中华皮肤科杂志 ›› 1986, Vol. 19 ›› Issue (5): 262-264.

• 论著 • 上一篇    下一篇

皮肤真性组织细胞性淋巴瘤及其体外瘤细胞株的建成Ⅰ.一例报告和文献复习

郑丙森1, 姬美蓉2, 许良中3, 刘亦法3   

  1. 1. 上海医科大学皮肤病学研究所皮肤病理室;
    2. 华山医院内科血液组;
    3. 肿瘤医院病理研究室
  • 收稿日期:1985-11-23 修回日期:1986-03-10 出版日期:1986-10-15 发布日期:1986-10-15

Cutaneous true histiocytic lymphoma and its tumor cell line：Ⅰ Report of a case and review of literature

Qiu Bingsen1   

  • Received:1985-11-23 Revised:1986-03-10 Online:1986-10-15 Published:1986-10-15

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摘要： 女性患者57岁发生皮肤真性组织细胞性淋巴瘤.主要临床表现为单一形皮肤结节.初期一般情况较佳.体格检查和实验室检查无异常.组织病理示皮肤结节的整个真皮内胶原束间一致性瘤细胞弥漫性浸润,酶细胞化学、免疫学和超微结构证实其为不典型组织细胞.组织培养更进一步证实.体外瘤细胞株已建成(详见另文).采用COP方法治疗无效.加用CCNU疗效显著,后因白细胞减少停用而皮损复发.患者死于全身衰竭.病程1年8月.

Abstract: A female patient developed cutaneous true histiocytic lymphoma at the age of 57. The main clinical manifestation was mono-morphous cutaneous nodules. Initially her general condition was good. Physical and laboratory examinations showed no abnormalily. Histopathologically uniform tumor cells diffusely infiltrated among the collagen bundles throughout the whole dermis of cutaneous nodules and were proved to be atypical histiocytes enzymically, immunologically and ultrastructurally and were further confirmed by tissue culture. The tumor cell line has been established in vitro(details in other paper). The COP regime for treatment had no effect while marked effect was obtained by adding CCNU. On account of leukopenia skin lesions recurred after with drawing of this drug. The patient died from cachexia. The whole course was one year and eight months.