中华皮肤科杂志 ›› 1985, Vol. 18 ›› Issue (3): 158-159.

• 论著 • 上一篇    下一篇

HLA和寻常型银屑病相关的研究

徐星培1, 郑从义2, 李全会1, 汪超英1, 吴淑荣3   

  1. 1. 卫生部武汉生物制品研究所;
    2. 武汉大学生物系微生物教研室;
    3. 湖北医学院一附院免疫室
  • 收稿日期:1983-12-15 出版日期:1985-09-15 发布日期:1985-09-15

Study on the association of HLA with psoriasis vulgaris

Xu Xingpei1   

  • Received:1983-12-15 Online:1985-09-15 Published:1985-09-15

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摘要： 我们调查了50个寻常型银屑病患者的HLA型和疾病相关性.结果表明HLA-B13(RR=3.74)和HLA-B17(RR=2.44)频率升高和国外报导的一致.而Aw19(RR=2.13)和Cw4(RR=6.35)频一率升高.Bw16(RR=0.17)和Cw3(RR=0.49)下降是本文首终担导,尚未见其他报告,期望同行们证实此发现.银屑病患者具有A1,B17的单倍型.A1与B17连锁,联系到A1,B17,B13抗原频率上升.可能这些抗原与银屑病易感基因相连锁.

Abstract: The association of HLA with psoriasis vulgaris has been investigated. We typed the HLA antigens of 50 patients with psoriasis vulgaris: Our results showed:The higher frequencies of HLA-B13(RR=3.74)and HLA-B17(RR=2.44) are coincident with those reported by other researchers abroad. It seems that this is the common characteristic between the Caucasians and Orientals. Both the increase of frequencies of HLA-Aw19(RR=2.13)and HLA-Cw4(RR=6.35)and the decrease of HLA-Bwls(RR=0.17)and HLA-Cw3(RR=0.49) are reported for the first time: No other data have ever been published so far. We hope more data could be obtained to identify our results. The relative risk values of patients with the haplotype of HLA-Al and HLA-B17(RR=18.95 P<0.001)are very significant statistically from any other haplotype. So that HLA haplotype is used as a marker to trace the inheritance pattern of closely linked disease susceptibility genes.