中华皮肤科杂志 ›› 1984, Vol. 17 ›› Issue (4): 249-251.

• 论著 • 上一篇    下一篇

银屑病患者血清环化核苷酸测定

倪容之1, 王克淦1, 夏纪青1, 常愈明2, 许瑞吉2, 连冬友2   

  1. 1. 南京部队总医院皮肤科;
    2. 南京部队总医院实验科
  • 出版日期:1984-12-15 发布日期:1984-12-15

Determination of serum cyclic nucleotides levels in psoriasis

Ni Rongzhi1   

  • Online:1984-12-15 Published:1984-12-15

PDF (PC)

269

赞

摘要： 我们测定了51例银屑病患者血清中的CAMP,cGMP.CAMP采用蛋白竞争法,cGMP采用放射免疫法.正常人和银屑病患者之间比较,CAMP没有显著性差别(P>0.05),cGMP差别非常显著(P<0.01).cAMP/cGMP比值在正常人为1.71,而银屑病患者为1.02.cGMP在银屑病患者与正常人比较,疹多组P<0.01,中等组0.01

Abstract: The cyclic AMP and the cyclic GMP in the sera were assayed from fifty one patients with psoriasis. The cyclic AMP was determined by competitive protein-binding method and the cyclic GMP by radioimmunoassay.The values of the cyclic AMP hail no difference (P>0.05) and the values of the cyclic GMP were significantly different (P<0.01) between the normal individuals and the psoriatic patients. The ratio of the cyclic AMP and the cyclic GMP was 1.71 in the normal individuals and 1.02 in the psoriatic patients.The extent of the eruptions was not related to the level of cyclic AMP and was closely related to the level of cyclic GMP.The values of cyclic A1V1P were of no statisticf difference and the values of cyclic GMP were significantly different between the progressive stage and the static stage of the patients. Cytotoxic drugs might obviously reduce the level of cyclic GMP in the sera and gave no effect to cyclic AMP.The authors also discussed the mechanism through which cyclic nucleotides participated in the regulation and the control of proliferation and differentiation of the epitlielial cells.