中华皮肤科杂志 ›› 1983, Vol. 16 ›› Issue (3): 138-142.

• 论著 •    下一篇

抗双链DNA抗体、抗核抗体的消长同SLE临床表现的关系Ⅱ.对9例活动期患者的连续观察

徐世正1, 李洪迥1, 王慧珍2   

  1. 1. 中国医学科学院首都医院皮肤科;
    2. 中国医学科学院首都医院检验科
  • 出版日期:1983-09-15 发布日期:1983-09-15

Anti-ds-DNA antibodies, ANA and SLE：Ⅱ.serial observations in 9 active patients

Xu Shizheng1   

  • Online:1983-09-15 Published:1983-09-15

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摘要： 本文对9例系统性红斑狼疮(SLE)进行了连续观察,发现用马疫锥虫兔疫荧光法(TE-IF法)测定抗双链DNA抗体(dsDNA)和抗核抗体(ANA)的消长变化,与病情的活动密切相关.活动期抗dsDNA滴度明显升高,缓解期下降或转阴.抗体水平升高先于症状的出现或加重,长期高滴度者示治疗不足,可能发展为肾病综合征.ANA滴度变化与抗dsDNA相似,只是滴度下降缓慢些.大剂量皮质类固醇激素可使血清抗dsDNA水平迅速降低.TE-IF和Farr氏两法之相关分析结果显示正相关(活动期r=0.6833, P<0.05).用TE-IF法定期测定抗dsDIVA和ANA,对于监视病情和指导治疗有一定参考意义.

Abstract: A follow-up study of 9 patients with systemic lupus erythematosus(SLE)has been made through a serial clinical and Iabofatory investigations, It showed that the titers of antinuclear antibodies (ANA)and anti-ds-DNA antibodies was determined by Trypanosoma equiperdum indirect immunofluor-escent method(TE-IF)correlated closely with the activity of SLE, During the active stage the titers remained high, and during remission they became low or even aegative.The clinical exacerbation was preceeded by a steady rise of the titer, A sustained high titer may mean inadequacy of treatment and a premonition of developing nephrotic syndrome, Changes in the titers of ANA and anti-ds-DNA antibodies were similar, but the former were comparatively slower. Administration of large doses of corticosteroid caused a rapid dr op of the titer of anti-ds-DNA antibodies,The result of correlational analysis showed positive correlation between TE-IF and Farr assay(active stage; r=0.6833, P<0.05).Serial determinations of anti-ds-DNA antibodies and ANA by TE-IF at a regular interval are considered to be of value in the treatment and surveillance of SLE.