中华皮肤科杂志 ›› 1982, Vol. 15 ›› Issue (4): 199-201.

• 论著 •    下一篇

雷公藤总甙治疗某些皮肤病的研究

雷公藤研究组   

  1. 中国医学科学院皮肤病研究所
  • 出版日期:1982-12-15 发布日期:1982-12-15

Lei Gong Teng(Trypterygium Wilfordii Hook.f.)total glucosides:Study of its therapeutic effect in certain dermatoses

Lei Gong Teng Study Group, Institute of Dermatology, Chinese Academy of Medical Sciences   

  • Online:1982-12-15 Published:1982-12-15

摘要: 本文报告雷公藤有效组分—雷公藤总甙(简称总贰)治疗200例各种皮肤病,包括Sweet综合征、变应性血管炎、湿疹、多形红斑、Behcet综合征、红皮病及关节病型银屑病等.其疗效确切,见效较快.没有皮质激素的副作用,可用于某些对皮质激素有依赖、抗药及禁忌的患者.实验证明,总试有明确的抗炎和免疫抑制作用.这是治疗许多变应性、自身免疫性疾病的药理基础.常见的副作用为消化道反应及白细胞降低,但不影响治疗.女性患者可有月经紊乱,动物实验发现可抑制肇丸生精上皮,因而,儿童及育龄患者宜慎用,孕妇禁用.

Abstract: Lei-Gong-Teng total glycosides(TG).an extract of Chinese medicinal lierb Lei-Gong-Teng was used to treat 200 cases of various dermatoses, including Sweet's syndrome, allergic angiitis,eczema, erythema multiforme, Behcet's disease, erythroderma and psoriatic arthritis etc. It has bees found that TG exerted an effective therapeutic action on these diseases, and the response was rather quick. It was found that TG had no side-effect of the steroids, and no rebound phenomenon after its dis-continuance. Therefore, TG can be used in patients who are steroid-dependent, steroid resistant or contra-indicated. TG is useful in immunologic and inflammatory diseases because of its potent immuno-suppressive action and anti-inflammatory action which were experimentally demonstrated. The side-effects of TG are less and milder than those of the crude drug of Lei-Gong-Teng,The commonest side-effects of TG are disturbances of digestive system, but these reactions would subside spontaneously.Leukopenia occurred in a few patients, but returned to normal soon after discontinuance of the drug. Caution should be paid to its use in child-bearing age patients and in pregnant women.