Abstract:

Yin Dong, Gao Jianwu, Yang Li, Yang Fan Department of Dermatology, Shaanxi Provincial People′s Hospital, Xi′an 710068, China Corresponding author: GaoJianwu, Email: jianwugao@126.com 【Abstract】 Objective To improve the understanding of cavernous lymphatic malformation（CLM）of the vulva. Methods The clinical manifestations, histopathological and immunohistochemical features of a case of CLM involving bilateral labia minora were analyzed, and relevant literatures were reviewed. Results A 17-year-old unmarried female patient presented with gradually enlarged subcutaneous masses on the bilateral labia minora for 2 years. Physical examination showed that soft kidney-shaped subcutaneous masses were observed on the bilateral labia minora. After surgical resection, a yellow-white solid cut surface was observed, and there were scattered rice-sized cyst cavities filled with clear colorless liquid. Histopathologically, a large number of dilated lymphatic vessels with different sizes of lumens were scatteredly distributed in the dermis. The lumens were lined by a single layer of flattened endothelial cells, and there were thick fibrous septa between the lumens. Endothelial cells in the lymphatic vessels were stained positive for D2-40 and CD31, but negative for CD34. Interstitial fibroblasts were stained positive for progesterone receptors, but negative for estrogen receptors. Finally, the patient was diagnosed with CLM of bilateral labia minora. After surgical resection of the masses on the bilateral labia minora, no relapse was observed during the follow-up of 6 months. Conclusion Histopathological and immunohistochemical features facilitate the diagnosis and differential diagnosis of CLM.