中华皮肤科杂志 ›› 2023, e0230003.doi: 10.35541/cjd.20230003

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单细胞转录组测序技术在皮肤组织中的注释及运用

何月希    常建民   

  1. 北京医院皮肤科  国家老年医学中心  中国医学科学院老年医学研究院,北京  100730
  • 收稿日期:2023-01-03 修回日期:2023-08-28 发布日期:2023-12-12
  • 通讯作者: 常建民 E-mail:changjianmin@medmail.com.cn
  • 基金资助:
    中央高水平医院临床科研业务费专项(BJ-2022-126);国家自然科学基金(82203919)

Cell annotation and application of single-cell RNA sequencing in skin tissues

He Yuexi, Chang Jianmin   

  1. Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2023-01-03 Revised:2023-08-28 Published:2023-12-12
  • Contact: Chang Jianmin E-mail:changjianmin@medmail.com.cn
  • Supported by:
    National High-level Hospital Clinical Research Funding (BJ-2022-126); National Natural Science Foundation of China (82203919)

摘要: 【摘要】 单细胞RNA测序技术(scRNA-seq)是从单个细胞水平研究基因序列、细胞异质性、细胞间相互作用等的新兴技术,细胞注释是其中的关键步骤。目前scRNA-seq在皮肤科疾病中应用逐渐增多,本文就scRNA-seq在皮肤组织中检测到的细胞群标记基因及亚群功能进行综述。

关键词: 转录组, 单细胞分析, 皮肤, 基因组学

Abstract: 【Abstract】 Single-cell RNA sequencing(scRNA-seq) is an emerging technology to study gene sequences, cell heterogeneity and cell-cell interaction at the single-cell level, and cell annotation is a key step. At present, the application of scRNA-seq technology in dermatological diseases is gradually increasing. This review summarizes the function of scRNA-seq technology in the detection of marker genes of cell groups and subsets in skin tissues.

Key words: Transcriptome, Single-cell analysis, Skin, Genomics

引用本文

何月希 常建民. 单细胞转录组测序技术在皮肤组织中的注释及运用[J]. 中华皮肤科杂志, 2023,e0230003. doi:10.35541/cjd.20230003

He Yuexi, Chang Jianmin. Cell annotation and application of single-cell RNA sequencing in skin tissues[J]. Chinese Journal of Dermatology,2023,e0230003. doi:10.35541/cjd.20230003