中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (1): 1-4.doi: 10.35541/cjd.20220422

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【开放获取】典型与非典型表现的特应性皮炎

李巍,李政   

  1. 复旦大学附属华山医院皮肤科，上海  200040
  • 收稿日期:2022-06-13 修回日期:2022-08-14 发布日期:2023-01-03
  • 通讯作者: 李巍 E-mail:liweiderma@fudan.edu.cn
  • 基金资助:
    国家自然科学基金（81972939）

Atopic dermatitis with typical and atypical manifestations

Li Wei, Li Zheng    

  1. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2022-06-13 Revised:2022-08-14 Published:2023-01-03
  • Contact: Li Wei E-mail:liweiderma@fudan.edu.cn
  • Supported by:
    National Natural Science Foundation of China（81972939）

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摘要： 【摘要】 特应性皮炎（AD）是一种高度异质性的皮肤病，临床表现差异较大。早期的AD研究主要关注婴幼儿起病的AD，其典型皮损表现为以屈侧为主的湿疹样皮炎，大多合并遗传过敏性素质；而成人AD和老年AD中，分布和形态不典型的皮损较常见，如伸侧为主分布以及痒疹等多形性皮疹。目前临床上对于皮损形态、发病部位以及起病年龄等不典型的AD认识不够，在一定程度上降低了AD的诊断率。本文描述AD典型和非典型表现的临床特点，以增进我国皮肤科医生对AD的认识。

关键词: 皮炎, 特应性, 皮肤表现, 诊断, 临床表型

Abstract: 【Abstract】 Atopic dermatitis （AD） is a highly heterogeneous skin disease with various clinical manifestations. Early studies mainly focused on infant-onset AD, which is characterized by typical skin lesions such as eczematous dermatitis on the flexor sites accompanied by genetic predisposition to other allergic diseases; however, atypical manifestations and distributions of skin lesions are common among adult AD and elderly AD, e.g., distribution mainly on the extensor sites and polymorphic rashes such as prurigo nodularis. Many dermatologists are not familiar with atypical manifestations of AD, including atypical manifestations and distributions of skin lesions as well as atypical age at onset, which decreases the diagnostic rate of AD to a certain extent. This article delineates clinical features of AD with typical and atypical manifestations, in order to promote the understanding of AD among Chinese dermatologists.

Key words: Dermatitis, atopic, Skin manifestations, Diagnosis, Phenotype