中华皮肤科杂志 ›› 1986, Vol. 19 ›› Issue (1): 12-14.

• 论著 • 上一篇    下一篇

应用单克隆抗体及ABC技术对2例蕈样肉芽肿皮肤浸润细胞表一现型的初步观察

李伯壎1, 司履生2, 李恒力2   

  1. 1. 西安医学院皮肤病教研组;
    2. 西安医学院病理解剖教研组
  • 收稿日期:1985-03-06 修回日期:1985-07-10 出版日期:1986-02-15 发布日期:1986-02-15

  • Received:1985-03-06 Revised:1985-07-10 Online:1986-02-15 Published:1986-02-15

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摘要：

本文应用ABC技术和各种标定T和B淋巴细胞亚群的单克隆抗体对两例典型MF患者的皮肤组织冰冻切片进行了检测.发现如下:单克隆杭体T11阳性的浸润细胞在两例中分别78%和68%,而未发现有阳性B细胞.T细胞中,T4性细胞分别为47%及48%,而T8阳性细胞分别为20%和25%;T4与T8阳性细胞之比约为2:1.此外.1例I2阳性细胞为69%.

Abstract:

Frozen sections of skin tissue taken from two typical cases of MF were examined by the use of sensitive ABC techinque and various monoclonal antibody for defining T and B lymphocyte subsets. Our findings were as follows: 78% and 68% of the infiltrating cells in the specimens from two patients were T11 positive cells, whereas no B cells were found. Among T cells, T4 positive cells were 47% and 48% respectively, while Ts positive cells were 20% and 25%. The ratio between T4 and T8 was about 2:1. Besides, in one of our cases, I2 positive cells were 69%.