中华皮肤科杂志 ›› 1984, Vol. 17 ›› Issue (2): 81-84.

• 论著 • 上一篇    下一篇

丙硫异菸胺合并利福平(或R761)和氨苯矾治疗多菌型麻风的毒副作用的观察

江苏省扬州地区麻风病化疗研究协作组   

  1. 中国医学科学院皮肤病研究所麻风病研究室
  • 出版日期:1984-06-15 发布日期:1984-06-15

Toxicity of prothiomide plus rifampicin(or isobutylpiperazinyl rifamycin)and dapsone in the treatment of multibacillary leprosy

Department of leprology, Institute of Dermatology, Chinese Academy of Medical Sciences   

  • Online:1984-06-15 Published:1984-06-15

PDF (PC)

360

赞

摘要： 木文对丙硫异菸胺(PTH)合并利福平(RFP)和氨苯砜以及PTH合并异丁基呱嗪力复霉素(R761)和氨笨砜(治疗组)治疗多菌型麻风的毒副作用进行了观察,并分别与不含PTH的相应对照组进行了比较.治疗期为半年.结果发现合并PTH的治疗组的毒性明显增加.与相应对照组相比有显著差异.主要毒副作用为肝脏损害.在PTH合并RFP和氨苯矶治疗组有一例在治疗6个月时因急性黄色肝萎缩而死亡.上述结果表明治疗组的毒性增加与PTH有关,因此PTH合并RFP或R761和氨笨破不能广泛用于多菌型麻风的治疗.

Abstract: The toxicity of prothiomide(PTH)+rifam-picin(RFP)+Dapsoae and PTH+isobutylpiperaziayl rifamycin(R761)+Dapsone(treatment groups)in the treatment of multibacillarp leprosy were compared with the corresponding control groups that did not include PTH. The duration of treatment was 6 months. The results showed that the toxicity of the treatment groups with PTH increared remarkably, and was different significantly in comparing with the corresponding control groups without PTH. The main toxic side effect was liver damage. One.patient died of acute yellow atrophy of the liver in the treatment group(PTH-E-RFP+Dapsoae)at the end of 6 months of treatment. The results indicated that the increase of toxicity of the treatment groups was related to PTH. So, PTH in combination with RFP(or R761)and Dapsone should not be recommended for the treatment of multibacillarp leprosy in our country.